User:LightPear/sandbox

The multicatalytic enzyme CYP24 is used to deactivate 1,25-(OH)2D3 which ultimately results in the formation of calcitroic acid. Similar to 1,25-(OH)2D3 (vitamin D3), 1α,25-1,25-(OH)2D2 (vitamin D2) is also able to form calcitroic acid by undergoing side-chain oxidation and side-chain cleavage. However, it is done by an undefined route in cell cultures and organ perfusions. Experiments using purified rat CYP24 to deactivate 1α,25-1,25-(OH)2D2 have shown that there is no evidence of calcitroic acid production. Therefore, this suggests that producing calcitroic acid from 1,25-(OH)2D2 involves enzymes other than CYP24.

Uses and functions:

Studies have shown that administering calcitroic acid displays antirachitic and anti-inflammatory properties. Further studies will show if calcitroic acid can be used to treat bone diseases such as rickets and inflammatory diseases of the intestines such as inflammatory bowel disease.