User:Lilsharplilac/sandbox

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Virus Lifecycle
VHSV can either enter the host cell through fusion or endocytosis. It binds to a glycoprotein, called fibronectin, in the extracellular matrix. VHSV does its binding through integrin receptors. One of the genes found on VHSV virion, the NV gene, is able to keep apoptosis from occurring during the early part of the viral replication cycle. The replication lifecycle takes place in the cytoplasm, where the L protein creates mRNA transcripts. The whole lifecycle of VHSV is completed in 16 to 20 hours.

Function of Genes in Virus
There are 4 main genes in VHSV. The L protein is the protein polymerase, which creates mRNA transcripts and assists with genome replication. The G protein is the glycoprotein, which is made up of peplomers on the surface of the virus. This gene helps with virus assembly and interactions between the virus membrane and other cells. It also responds to pH fluctuations. The N protein forms the core of the virion structure.

Transmission
VHSV is usually spread through urine or ovarian fluid from the fish. The virus is transmitted through another fish swallowing it. In addition to these two modes of transmission, VHSV can be passed on from parent to offspring through the surface of the fish's egg.