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Dilson Rassier
Dilson Rassier is a Canadian, Brazil-born biophysicist. His area of expertise includes Muscle physiology and biophysics.

Education
1988:	Bachelor's Degree in Physical Education. Faculty of Physical Education. Federal University of Pelotas, Pelotas (R.S.), Brazil.

1991-1994:	Master of Science (M.Sc.) in Exercise Physiology. Federal University of Rio Grande do Sul, Porto Alegre (RS), Brazil. Thesis: Effects of human recombinant erythropoietin on hematological and hemodynamic parameters in athletes.

1994-1998:	Ph.D. in Muscle Physiology. Department of Medical Sciences, Faculty of Medicine. University of Calgary, Calgary, Alberta, Canada. Dissertation: Length-dependence of twitch potentiation in skeletal muscle.

Professional career
Dilson Rassier is a Professor/Dean - Faculty of Education, Canada Research Chair, Tier 1, in Muscle Biophysics at the Department of Kinesiology and Physical Education, McGill University whose Laboratory specializes in Muscle Physiology and Biophysics Lab. He is an Associate Member in the Department of Physiology and Pharmacology, (Faculty of Medicine, Karolinska Institute, Sweden), in the Departments of Physiology (Faculty of Medicine, McGill University) and Physics (Faculty of Science), and in the Meakins-Christie Laboratories.

Publications
1.	Pironti, G., Gastaldello, S., Rassier, D. E., Lanner, J. T., Carlström, M., Lund. L. H., Westerblad, H., Yamada, T., Andersson, D. C. Citrullination is linked to reduced Ca 2+ sensitivity in hearts of a murine model of rheumatoid arthritis. Acta Physiologica. Ahead of print, 2022.

2.	Pierantozzi, E., Szentesi, P., Paolini. C,, Dienes, B., Fodor, J., Oláh, T., Colombini, B., Rassier, D. E., Rubino, E. M., Lange, S., Rossi, D., Csernoch, L., Bagni, M. A., Reggiani, C., Sorrentino, V. Impaired intracellular Ca2+ dynamics, M-Band and sarcomere fragility in skeletal muscles of obscurin KO mice. International Journal of Molecular Sciences. 23(3):1319, 2022. 3.	Moretto, L., Ušaj, M., Matusovsky, O., Rassier, D. E., Friedman, R., Månsson, A. Multistep orthophosphate release tunes actomyosin energy transduction. Nature Communication. 13(1):4575, 2022.

4.	Sigoli, E., Antão, R. A., Guerreiro, M. P., de Araújo, T. O. P., Santos, P. K. D., da Roza D. L., Rassier, D. E., Cornachione AS. Effects of Low-Intensity and Long-Term Aerobic Exercise on the Psoas Muscle of mdx Mice: An Experimental Model of Duchenne Muscular Dystrophy. International Journal of Molecular Sciences. 23(9):4483, 2022.

5.	Contini, M., Altman, D., Cornachione, A., Rassier, D. E., Bagni, M. A. An increase in force after stretch of diaphragm fibers and myofibrils is accompanied by an increase in sarcomere length nonuniformities and Ca2+ sensitivity. American Journal of Physiology - Cell Physiology. 323(1):C14-C28, 2022.

6.	Elkrief, D., Cheng, Y. S., Matusovsky, O. S., Rassier, D. E. Oxidation alters myosin-actin interaction and force generation in skeletal muscle filaments. American Journal of Physiology - Cell Physiology. Ahead of print, 2022. 7.	Pierantozzi, E., Szentesi, P., Paolini, C., Dienes, B., Fodor, J., Oláh, T., Colombini, B., Rassier, D.E., Rubino, E.M., Lange, S., Rossi, D., Csernoch, L., Bagni, M.A., Reggiani, C., Sorrentino, V. Impaired intracellular Ca2+ dynamics, M-Band and sarcomere fragility in skeletal muscles of obscurin KO mice. International Journal of Molecular Sciences. 23(3): 1319, 2022.

8.	Matusovsky, O., Kodera, N., MacEachen, C., Ando, T., Cheng, Y.S., Rassier, D.E. Millisecond conformational dynamics of skeletal myosin II power stroke studied by high-speed AFM. ACS Nano. 15(2):2229-2239, 2021.

9.	Pedrazzani, P.S., Araújo, T.O.P., Sigoli, E., Silva, I.R., Roza, D.L., Chesca, D.L., Rassier, D.E., Cornachione, A.S. Twenty-one days of low-intensity eccentric training improve morphological characteristics and function of soleus muscles of mdx mice. Scientific Reports. 11(1):3579, 2021.

10.	Haeger, R.M., Rassier, D.E. Force enhancement after stretch of isolated myofibrils is increased by sarcomere length non-uniformities. Scientific Reports. 10(1):21590, 2020.

11.	Haeger, R., de Souza Leite, F.S., Rassier, D.E. Sarcomere length non-uniformities dictate force production along the descending limb of the force-length relation. Proceedings of the Royal Society B. 287(1937):20202133, 2020.

12.	Leite, F.S., Rassier, D.E. Sarcomere length non-uniformity and force regulation in myofibrils and sarcomeres. Biophysical Journal. 119(12):2372-2377, 2020.

13.	 Mendoza, A.C., Rassier, D.E. Extraction of thick filaments in individual sarcomeres affects force production by single myofibrils. Biophysical Journal. 118(8):1921-1929, 2020.

14.	van de Locht, M., de Winter, J.M., Rassier, D.E., Helmes, M.H.B., Ottenheijm, C.AC. Isolating myofibrils from skeletal muscle biopsies and determining contractile function with a nano-newton resolution force transducer. Journal of Visualized Experiments. (159), 2020.

15.	Cheng, Y.S., Leite, F.S., Rassier, D.E. The load dependence and the force-velocity relation in intact myosin filaments from skeletal and smooth muscles. American Journal of Physiology-Cell Physiology. 318(1):C103-C110, 2020.

16.	de Winter, J.M., Molenaar, J.P., Yuen, M., van der Pijl, R., Shengyi S., Conijn, S., Willigenburg, M., Bogaards, S., van Kleef, E., Lassche, S., Persson, M., Rassier, D.E., Sztal, T.E., Ruparelia, A.A., Bryson-Richardson, R.J., Johnson, C.N., Marabita, M., Blaauw, B., Rodenburg, R.J., Kϋsters, B., Beggs, A.H., Granzier, H., Campbell, K., Ma, W., Irving, T., Malfatti, E., Romero, N.B., Doorduin, J., van Engelen, B., Voermans, N., Ottenheijm, C.A.C. KBTBD13 is an actin-binding protein that modulates muscle kinetics. Journal of Clinical Investigation. 130(2):754-767, 2020.

17.	Li, A., Nelson, S.R., Rahmanseresht, S., Braet, F., Cornachione, A.S., Previs, S.B., O'Leary, T.S., McNamara, J.W., Rassier, D.E., Sadayappan, S., Previs, M.J., Warshaw, D.M. Skeletal MyBP-C isoforms tune the molecular contractility of divergent skeletal muscle systems. Proceedings of the National Academy of Sciences USA. 116(43):21882-21892, 2019.

18.	Persson, M., Steinz, M.M., Westerblad, H., Lanner, J.T., Rassier, D.E. Force generated by myosin cross-bridges is reduced in myofibrils exposed to ROS/RNS. American Journal of Physiology-Cell Physiology. 317(6):C1304-C1312, 2019.

19.	Moroz, N., Maes, K., Leduc-Gaudet, J.P., Goldberg, P., Petrof, B.J., Mayaki, D., Vassilakopoulos, T., Rassier, D.E., Gayan-Ramirez, G., Hussain, S.N. Oxidants regulated diaphragm proteolysis during mechanical ventilation in rats. Anesthesiology. 131(3):605-618, 2019.

20.	Matusovsky, O.S., Mansson, A., Persson, M., Cheng, Y-S., Rassier, D.E. High-speed AFM reveals sub-second dynamics of cardiac thin filaments upon Ca2+ activation and heavy meromyosin binding. Proceedings of the National Academy of Sciences USA. 116(33):16384-16393, 2019.

21.	Liang, F., Emeriaud, G., Rassier, D.E., Shang, D., Gusev, E., Hussain, S.N.A., Sage, M., Crulli, B., Fortin-Pellerin, E., Praud, J.P., Petrof, B.J. Mechanical ventilation causes diaphragm dysfunction in newborn lambs. Critical Care. 23(1):123, 2019.

22.	Steinz, M.M., Persson, M., Aresh, B., Olsson, K., Cheng, A.J., Ahlstrand, E., Lilja, M., Lundberg, T.R., Rullman, E., Ängeby Möller, K., Sandor, K., Ajeganova, S., Yamada, T.,. Beard, N., Karlsson, B.C., Tavi, P., Kenne, E., Svensson, C.I., Rassier, D.E., Karlsson, R., Friedman, R., Gustafsson, T., Lanner, J.T. Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis. JCI Insight. 5. pii: 126347, 2019.

23.	Bagni, M.A., Colombini, B., Nocella, M., Pregno, C., Cornachione, A., Rassier, D.E. The effects of fatigue and oxidation on contractile function of intact muscle fibers and myofibrils isolated from the mouse diaphragm. Scientific Reports. 9(1) 4422, 2019.

24.	Rassier, D.E., Kashina, A. Protein arginylation of cytoskeletal proteins in the muscle modifications modifying function. American Journal of Physiology-Cell Physiology. 316(5):C668-C677, 2019.

25.	Månsson, A., Persson, M., Shalabi, N., Rassier, D.E. Non-linear actomyosin elasticity in muscle? Biophysical Journal. 116 (2) 330-346, 2019.

26.	Cheng, Y.S., Matusovsky, O.S., Rassier, D.E. Cleavage of loops 1 and 2 in skeletal muscle heavy meromyosin (HMM) leads to a decreased function. Archives of Biochemistry and Biophysics. 661: 168-177, 2019.

27.	Lowey, S., Bretton, V., Joel, P.B., Trybus, K.M., Gulick, J., Robbins, J., Kalganov, A., Cornachione, A.S., Rassier D.E. Hypertrophic cardiomyopathy R403Q mutation in rabbit β-myosin reduces contractile function at the molecular and myofibrillar levels. Proceedings of the National Academy of Sciences (PNAS). 115(44):11238-11243, 2018.

28.	Rahman, M.A., Ušaj, M., Rassier, D.E., Månsson, A. Blebbistatin Effects Expose Hidden Secrets in the Force-Generating Cycle of Actin and Myosin. Biophysical Journal. 115(2):386-397, 2018.

29.	Månsson, A., Ušaj, M., Moretto, L., Rassier, D.E. Do Actomyosin Single-Molecule Mechanics Data Predict Mechanics of Contracting Muscle? International Journal of Molecular Sciences. 19(7). pii: E1863, 2018.

30.	Joureau, B., de Winter, J.M., Conijn, S., Bogaards, S.J.P., Kovacevic, I., Kalganov, A., Persson, M., Lindqvist, J., Stienen, G.J.M., Irving, T.C., Ma, W., Yuen, M., Clarke, N.F., Rassier, D.E., Malfatti, E., Romero, N.B., Beggs, A.H., Ottenheijm, C.A.C. Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3). Annals of Neurology. (2):269-282, 2018.

31.	Shalabi, N., Persson, M., Månsson, A., Vengallatore, S., Rassier, D.E. Sarcomere stiffness during stretching and shortening of rigor skeletal myofibrils. Biophysical Journal. 113(12):2768-2776, 2016.

32.	de Souza Leite, F., Minozzo, F.C., Altman, D., Rassier, D.E. Microfluidic perfusion shows intersarcomere dynamics within single skeletal muscle myofibrils. Proceedings of the National Academy of Sciences USA. 15;114(33):8794-8799, 2017.

33.	Kamandulis, S., de Souza Leite, F., Hernández, A., Katz, A., Brazaitis, M., Bruton, J.D., Venckunas, T., Masiulis, N., Mickeviciene, D., Eimantas, N., Subocius, A., Rassier, D.E., Skurvydas, A., Ivarsson, N., Westerblad, H. Prolonged force depression after mechanically demanding contractions is largely independent of Ca2+ and reactive oxygen species. FASEB Journal. 31(11):4809-4820, 2017.

34.	Rassier, D.E. Sarcomere mechanics in striated muscles: from molecules to sarcomeres to cells. American Journal of Physiology - Cell Physiology. 313(2):C134-C145, 2017.

35.	Shalabi, N., Cornachione, A., de Souza Leite, F., Vengallatore, S., Rassier, D.E. Residual force enhancement is regulated by titin in skeletal and cardiac myofibrils. Journal of Physiology (London). 595(6):2085-2098, 2017.

36.	Rassier, D.R., Minozzo, F.C. Length-dependent Ca2+ activation in skeletal muscle fibres from mammalians. American Journal of Physiology – Cell Physiology. 311(2):C201-C211, 2016.

37.	Leite, F.S., Kashina, A., Rassier, D.R. Posttranslational arginylation regulates striated muscle function. Exercise and Sport Sciences Reviews. 44(3):98-103, 2016.

38.	Hussain, S.N.A., Cornachione, A., Guichon, C., Khunaizi, A.K.L., Leite, F.S., Mofarrahi, M., Moroz, N., Varennes, B., Goldberg, P., Rassier, D.E. Prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax. 71(5):436-45, 2016.

39.	Cheng, A.J., Yamada, T., Rassier, D.E., Andersson, D.C., Westerblad, H., Lanner, J.T. Reactive oxygen/nitrogen species and contractile function in skeletal muscle during fatigue and recovery. Journal of Physiology (London). 594(18):5149-5160, 2016.

40.	Power, G.A., Minozzo, F.C., Spendiff, S., Filion, M.E., Konokhova, Y., Purves-Smith, M., Pion, C., Aubertin-Leheudre, M., Morais, J.A., Herzog, W., Hepple, R.T., Taivassalo, T., Rassier, D.E. Reduction in single muscle fiber rate of force development with aging is not attenuated in world class older master’s athletes. American Journal of Physiology - Cell Physiology. 310(4):C318-C327, 2016.

41.	Leite, F.S., Minozzo, F.C., Kalganov, A., Cornachione, A.S., Cheng, Y.S., Leu, N.A., Han, X., Saripalli, C., Yates, J.R. 3rd, Granzier, H., Kashina, A.S., Rassier, D.E. Reduced passive force in skeletal muscles lacking protein arginylation. American Journal of Physiology - Cell Physiology. 310(2):C127-C135, 2016.

42.	Cornachione, A.S., Leite, F.S., Bagni, M.A., Rassier, D.E. The increase in non-crossbridge forces after stretch of activated striated muscle is related to titin isoforms. American Journal of Physiology - Cell Physiology. 310(1):C19-C26, 2016.

i.	Article subject of an editorial focus: Hwee, D.T., Jasper, J.R. More roles for the (passive) giant. Focus on "The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms". American Journal of Physiology - Cell Physiology. 310(1):C17-C18, 2016.

ii.	Rassier, D.E. Reply to "Letter to the editor: Titin-actin interaction: the report of its death was an exaggeration", by Nishikawa, K. American Journal of Physiology - Cell Physiology. 310(7):C623, 2016.

iii.	Rassier, D.E. Reply to "Letter to the editor: Comments on Cornachione et al. "The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoforms", by W. Herzog, American Journal of Physiology - Cell Physiology. 311(1):C160-C161, 2016.