User:Lopcal/sandbox

[Week 6] 21/09/2020- 26/09/2020

Rotavirus Vaccine

The article I assigned myself was entitled Rotavirus vaccine and the article I am comparing it to is the article entitled Dengue. Even though the article I assigned myself was very specific discussing different aspects of Rotavirus vaccines, the article on Dengue also had a section on vaccine as well. Despite this, I was able to compare the quality of the articles.

Analysis of Dengue Article.

Pros

·      The article covered many aspects of the topic which is good even though some areas such as “drug research” may be required to be developed more.

·      The sources used for this article, at a glance, seem to be reliable. The number of sources used was good too.

·      The overall structure of the articles in terms of headings and subheadings was great. The images used were relevant to the section they were included in. Probably, more images or diagrams may be added to enhance the presentation of the information.

Cons

·      The lead paragraph did not provide a clear overview that was easy to understand. In my view, it included information that was out of place and did not allow for the article to have coherence.

·      In terms of grammar, a couple of sentences sounded awkward and probably a change in the sentence structure and word order would fix that. Also, wrong punctuation in a couple of sentences.

·      There are a couple of facts stated that were not cited.

·      In some instances, the article was not neutral. It seemed as if though the author of this article subtly included their views.

Analysis of Rotavirus vaccine Article

Pros

·      The lead section provided enough detail that was relevant and easy to understand.

·      The tone was overall neutral. I cannot pinpoint a section where the author subtly included their views.

Cons

·      Some sentences can be restructured to make thoughts more complete and ideas more connected. For example, by converting a simple sentence to a compound sentence.

·      There are a couple of facts or statistics stated that were not cited.

·      Some sentences were vague since it used words “Recently” which don’t provide an exact time frame.

·      The headings and subheadings used were relevant, but the order might not be the best one. For example, “History” followed by “society and culture” might fit better after the introduction and before “Medical uses” and the rest of headings.

·      This article requires the further development of different sections. The information at times is vague or not sufficient.

Outline of my article contribution to Rotavirus Vaccine Article

1.     Introduction (lead paragraph)

2.     History

3.    Society and Culture

a.Temporary Suspension

4.     Medical Uses

a.     Effectiveness

b.     Schedule

4.     Types of Vaccines [paragraph below added Week 7 [28/09/2020-03/10/2020]

Studies carried out in animal models pointed out that immune protection against rotavirus can be brought about in two ways: by passive transfer of immune products specific for RV or by vaccination. The observations made in young children showed that primary infections were generally asymptomatic in the first year of life. The other observation was that reinfections with RV were rare frequent in the first 2-3 years of life and antibodies present in the gut are linked to immunity developed by repeated natural exposure .These observations were crucial in recognizing this disease as preventable by vaccines .In the next few paragraphs, the different types of vaccines developed for rotavirus disease will be covered.

5.    Research

a.Improvement of vaccines

Vaccines are generally considered the most successful prophylactic interventions but the efficiency difference between high- and low-income countries correlates to the availability of resources. which include access to clean water and hygiene. Thus, the improvement of vaccines is required in an effort to overcome such limitations. Among improvement efforts is the optimization of vaccine delivery. In regions where environmental enteropathy is an issue, oral immunizations lead vaccines to have lower efficacy due to degradation by enzymes and mucus clearance. To fix this problem, another form of administration includes microneedle patches. Microneedle patches are advantageous since this transdermal delivery involves the dense connected network of antigen presenting cells that lie below the stratum corneum. Additionally, sublingual administration is another form of administration which confers more advantage over dermal administration due to the absence of keratinized cells in these tissues. Vaccines are also being improved through the addition of mucosal adjuvants. Adjuvants generally enhance the immune response, thus leading to lower and less frequent dosing especially in subunit and inactivated vaccines. Moreover, circadian rhythms play an important in vaccine improvements due to their influences in immune response. Moreover, the circadian rhythms of which approximately 10% of the genome is controlled by plays an important role in immunity. The circadian clock is important to reduce costs associated with immunity and enhancement of organismal fitness.

7.    References 8.    Further Reading

9.    External Links

Week 9 [10/11-10/17]

Response to Aced 24 Peer Review

The suggestions made by this peer reviewer were applied and after I made the edits, my draft was more accurate and complete. The suggestions made helped fill in the gaps of information I was not aware that was missing to clarify the information. Overall, the suggestions were helpful and relevant to my writing.Thanks for your suggestions Aced 24!