User:Lovinne/sandbox

HW for 9th week (3/7) Intentions for Edit of Phosphatase Article
 * Peer review: nicotanimide, RNA pol II
 * Look for...
 * Clarity
 * completeness of coverage
 * organization
 * media
 * linked words
 * redundancy
 * sources

I want to improve and expound upon the following aspects of the enzyme phosphatase: Preliminary Bibliography
 * Write a more detailed general description of the enzyme that addresses its general function, what class of enzymes it belongs to, and a brief overview of its roles in the body.
 * Explore the general catalytic mechanism of phosphatase.
 * Address significant aspects of physiological relevance
 * Write in greater detail about 3 major types of phosphatase, including definition, mechanism, and physiological relevance. Briefly discuss sub-classes.
 * Protein phosphatase
 * Mechanism
 * Subtypes: Ser/Thr, His, metallo-dependent
 * Role in signal transduction cascades, protein regulation,
 * Alkaline phosphatase
 * Mechanism
 * Roles in digestion, agriculture, cancer
 * Alkaline phosphatase
 * Mechanism
 * Roles in intestinal homeostatis, liver/bone/kidney, and developmental biology
 * Briefly overview significant uses of phosphatase inhibitors in drugs
 * 1) Fundamentals of Biochemistry; Voet, Voet, and Pratt (ISBN 978-1-118-91840-1)
 * 2) Direct determination of phosphatase activity from physiological substrates in cells (DOI: 10.1371/journal.pone.0120087).
 * 3) Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (DOI: 10.1126/scisignal.2004712)
 * 4) Human HAD phosphatases: structure, mechanism, and roles in health and disease (DOI: 10.1111/j.1742-4658.2012.08633.x)
 * 5) How do inhibitory phosphatases work?

Homework due 2/21: Homework due 2/14: Homework for next week:
 * Check out ChemDraw
 * Okay images: self-made, public domain, wikimedia commons, copyrighted w/ free license
 * First draft due next week; print hard copy for Dr. Tienson to annotate
 * Complete media training
 * Post proposed outline to talk page of phosphatase article.
 * By tomorrow, update class dashboard name to reflect chosen article.
 * By Tuesday, post first five sources of bibliography to user page. (copy DOI, insert)
 * WP:REFB
 * WP:CITE