User:Lucasveillon/sandbox

Synchronous precursor selection (SPS) is a technique used in mass spectrometry to improve MS3 sensitivity by isolating and cofragmenting multiple fragment ions in the MS2 spectrum using isolation waveforms with multiple frequency notches. The result is a ten-fold increase in the number of MS3 reporter ions over standard MS3 methods. By increasing the reporter ion signals, SPS improves the dynamic range of reporter ion quantitation, reduces reporter ion signal variance, and ultimately produces more high-quality quantitative measurements. The SPS-MS3 method is available on the Orbitrap Fusion, which leverages advancements in software and hardware to provide increased scan rates and improved sensitivity, resolution, and quantitative accuracy.