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Phosphatidylinositol phosphate (PIP) is a glycerophospholipid. PIP is produced from the phosphorylation of PI, which primarily forms PI(3)P and PI(4)P. Specifically, Phosphoinositide 3-kinase produces PI(3)P from Phosphatidylinositol.

Similar to other phosphatidylinositols, PIP also exhibits polymorphic behaviour.

PI(3)P Binding Module
Several studies have identified a PI(3)P binding module, the FYVE domain. The FYVE domain is named after the cysteine-rich proteins, Fab1p, YOTB, Vac1p, and early endosome antigen 1 (EEA1), and has been connected to vacuolar protein sorting and endosome function. . The proteins are characterized by having basic amino acids around the cysteines, and are able to coordinate with Zinc atoms. The metal coordination and basic amino acids are required for the acidic head group of PI(3)P to bind to the FYVE domain. It has been speculated these bindings cause conformational changes or regulate protein-protein or lipid-protein interactions.