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Professor Blastoff was a comedy podcast, hosted on the Earwolf comedy podcasting network.

= Professor Blastoff = The show originally aired in May 2011, and aired its last episode in July 2015. Most of the episodes were recorded at the Earwolf studio in Los Angeles, California. Professor Blastoff was hosted by three comedian friends: Tig Notaro, Kyle Dunnigan, and David Huntsberger.

Tig Notaro is a stand up-comic, writer, and actress. She gained popularity after releasing a comedy special (Tig Notaro: Live), that featured her experience after her mother's unexpected death and being diagnosed with breast cancer. Notaro has a Showtime documentary about her life and career post-cancer called Knock Knock, It's Tig Notaro. In September 2016, she co-wrote, produced, and starred in a show loosely based on her life titled One Mississippi.

Kyle Dunnigan is stand-up comic, writer, and actor. He has appeared on talk shows such as Late Night with Conan O'Brien, Jimmy Kimmel Live!, and The Late Late Show with Craig Ferguson. Dunnigan is a writer and actor in various skits on the show Inside Amy Schumer. In 2015, he won an Emmy Award for Outstanding Original Music and Lyrics.

David Hunstberger an american comedian. He has recorded three comedy CDs: Hello Robot (2005), Humanitis (2011), and Explosion Land (2013). In 2015 he began hosting the Syfy show titled Reactor.

The podcast focused on topics of science, philosophy, and humanities. Each episode featured a guest that had specific knowledge of that week's topic. The format of the show involved a fabricated backstory where a lost Professor transmitted data to the trio from space. Fans of the show refer to themselves as "Blastronauts".

Reception
In 2012, the show was also listed in Popular Science's list of "The Best Science Podcasts For The Enjoyment Of Your Ears and Brain".

The podcast was also listed at number 9 in Rolling Stone's "20 Best Comedy Podcasts Right Now" in 2014.