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Vecna (portrayed by Jamie Campbell Bower as an adult; also starring season 4; and Raphael Luce as a child) is a murderous being in the Upside Down, who first appears in season four. He preys on individuals reeling from past traumas, and his method of killing involves inducing nightmarish visions before telekinetically breaking their bones and imploding their skulls. He operates out of the Creel House in the Upside Down. He is revealed to have been the main antagonist of the series, being responsible for the events that terrorized Hawkins in the previous seasons back to Will's capture.

Vecna is revealed to be the main villain in Stranger Things[|Stranger Things]. Henry Creel(A.K.A Vecna), Victor Creel's son who was born with telepathic abilities. Henry grew up with a deeply misanthropic view of humanity after being ostracized throughout his childhood. He came to resent his family for their perceived hypocrisy, having learned that his father mistakenly bombed the home of an innocent family during World War II. In the 1950s, he terrorized and murdered his mother and sister in his family's house using his powers, but the exertion put him in a coma while his father was arrested for the murders and placed in a psychiatric institution. Henry was placed in the care of Dr. Brenner, who changed his name to Peter Ballard so that he could not be found, and who made him test subject One in his attempts to replicate his powers in other children. As an adult, Henry was made an orderly at Hawkins Lab to help oversee Brenner's experiments on a number of superpowered children including Eleven. Brenner placed an implant (dubbed "Soteria") in Henry's neck that suppressed his powers. In 1979, Henry befriended Eleven amidst her being bullied by other subjects and pointed out to her that she and the rest of the lab's occupants were prisoners. Sympathizing with Henry's plight after witnessing him being punished by Brenner, Eleven destroyed the Soteria implant, restoring his powers. Henry massacred all the other children and most of the lab's staff and attempted to kill Eleven after she refused to help him eradicate the rest of humanity. Eleven overpowered Henry and sent him into the Upside Down, where he became disfigured by lightning injuries and prolonged exposure to its toxic environment. Henry discovered various creatures residing in the realm and used his powers to control them, the Mind Flayer being the result of his manipulations.

In 1986, after spending several years remaining dormant and growing stronger while controlling the Upside Down, Henry begins terrorizing Hawkins himself, murdering several Hawkins High School students including Chrissy Cunningham, Fred Benson, and Patrick McKinney. Dustin and Eddie dub him "Vecna" based on his similarities to the Dungeons & Dragons character of the same name. Vecna nearly kills Max until her friends find a way to break his influence using music. He later possesses Nancy, reveals to her his past, and then shows her a vision of the future where Hawkins is torn apart by rifts before releasing her. Nancy and her friends deduce that Vecna needs to open four gates to the Upside Down to enact his plan, three of which have been spawned at the site of each of his murders. Max attempts to bait Vecna while her friends travel to the Upside Down to kill him. Eleven enters Max's mind and confronts Vecna, who reveals himself as the mastermind behind Upside Down's past attacks on Hawkins. Vecna possesses and kills Max before Eleven overpowers him, while Steve, Nancy, and Robin severely injure his physical form before he escapes. Though Eleven revives Max, her brief death opens the fourth gate to the Upside Down, releasing rifts that tear through Hawkins, allowing the Upside Down to begin infiltrating the town.