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Genetics research studying Late Life Depression focuses on identifying associated genetic markers linked to the development of Late-Life Depression. It is understood that genetic variants of APOE, BDNF, and SLC6A4 may be attributed to an increased risk (Tsang et al.). Regions of the brain that have been associated with these variants are hippocampal remodeling and the endocrine pathway of the Hypothalamus-Pituitary-Adrenal axis upon encountering stressful circumstances.