User:MRodriguezGarcia/MYO5A

Myosin Va (MYO5A)

Myosin Va is a motor protein in charge of the transport of vesicles, organelles and protein complexes along the actin filaments.

In the presence of cargo adapters and calcium, myosin Va is present in a elongated and active state. Myosin V have a N-terminal head domain and a C-terminal tail domain. The actin-binding head (N-Terminal) of myosin V is an ATP-dependent motor domain that transmit changes from the active site to the light chain lever arm. The C-terminal globular domain (GB) decides the myosin class and moderate the cargo transport. Also, the GB interacts with other cargo specific proteins. Myosin Va is highly expressed in neurons and melanocytes.

Myosin Va can regulate axonal vesicle transport on the actin filaments. The GB of MYO5A can form a complex with Rab3A. The involvement of this complex is important for the synaptic vesicles (SVs) trafficking of neurotransmitters and the dynamics of the SVs on the actin filaments.

MYO5a and MYO5b are involved with Kv1.5 (encoded by KCNA5) in the myocytes. Kv1.5 is associated with the regulation of the action potential in the myocytes. New strategies targeting Kv1.5 current through MYO5a and MYO5b in human atrial fibrillation (AF) are being studied.