User:MTRLQ/Rac (GTPase)

Lead
Copied from the article: "Rac is a subfamily of the Rho family of GTPases, small (~21 kDa) signaling G proteins (more specifically a GTPase). Just as other G proteins, Rac acts as a molecular switch, remaining inactive while bound to GDP and activated once GEFs remove GDP, permitting GTP to bind.  In its activated state, Rac participates in the regulation of cell movement, through its involvement in structural changes to the actin Cytoskeleton. "

The abnormal activities of Rac including its hyperactivation, resistance to degradation, and abnormal localization of its signaling protein components were found to facilitate the development of cancerous cells and resist to anticancer treatment.

The subgroup include:


 * Rac1
 * Rac2
 * Rac3
 * RhoG

Some research has suggested that Rac could be involved in mediating the process of forgetting.