User:MadelineJuliette/sandbox

OUTLINE-

Classification: Only autosomal dominant syndrome of neurodegeneration with brain iron accumulation. Iron brain disorder.

Signs and Symptoms or Characteristics: Iron accumulation in the brain, neurodegeneration.

Causes: Genetic neurodegeneration with brain iron accumulation, mutations in genes that encode proteins that are involved in iron metabolism.

Diagnoses: In older brains, iron accumulates in the same regions that are affected by both Alzheimer's disease and Parkinson's disease.

Epidemiology: Discovered in 2001, extended pedigree in the northeast of England; however, expanding throughout globe.

Neuroferritinopathy is an iron brain disorder. It is a neurodegenerative disease with the accumulation of iron in specific brain regions caused by the genetic mutation of certain proteins that are involved with the metabolism of iron in the brain. Currently, Neuroferritinopathy is the only neurodegenerative disease with an iron accumulation in the brain classified as an autosomal dominant syndrome.

There are multiple different iron brain disorders that are divided into three different categories: genetic neurodegeneration with brain iron accumulation, genetic systemic iron accumulation with neurologic features, and acquired diseases associated with iron excess or iron deficiency, with Neuroferritinopathy falling into the first category of genetic neurodegeneration with brain iron accumulation.

Neuroferritinopathy was discovered in 2001 and the majority of patients have been diagnosed in northeast England; however, multiple more cases have been diagnosed around the rest of the world in recent years. Because the iron that accumulates in the brain increases over longer periods of time, Neuroferritinopathy is primarily seen in older adults, specifically in adults affected by Alzheimer’s disease or Parkinson’s disease.