User:Maftuna96/sandbox

Overexpression of PVT1 is associated with many cancers, one of which is Prostate Cancer. The overexpression of PVT1 in Prostate Cancer downregulates the miR-146a gene that leads to a decrease of miR-146a levels in a cell, through the methylation of CpG island on its promotor region, promoting the suppression of the cancer cell apoptosis.