User:Malam8/sandbox

Furthermore, later study have shown that purify form of TcdB is more lethal enterotoxin in comparison to TcdA, and intestinal epithelium is severely damage that ultimately causes to have an acute inflammatory response. With better understanding of the toxin, researchers were able to stating that TcdB is the major virulence factor that causes CDI rather TcdA. However, when TcdA is present in the gut, it helps to facilitate TcdB to have a border impact which ultimately leads to affecting multiple organs system. In addition, when hamsters were vaccinated against TcdA, it shows hamsters were not fully protected from the C. difficile disease and this lead studies to conclude TcdB also very lethal and potent. Furthermore, by injecting small dose of TcdA with the lethal dose of TcdB intravenously or intraperitoneally is sufficient to the cause death of an animal. This shows that TcdA is a facilitator of TcdB for exiting from the gut.