User:Malini Olivo/sandbox

Professor Malini Olivo - Ph.D. Biomedical Physics

 * Lab Head
 * Bio-optical Imaging Group
 * Singapore Bio-Imaging Consortium (SBIC),
 * 11 Biopolis Way, #02-02 Helios,
 * Singapore 138667
 * 6478 8752
 * Malini_Olivo@sbic.a-star.edu.sg

Biography
Malini Olivo is currently head of Bio-Optical Imaging Group, Singapore Bioimaging Consortium, A*STAR, Singapore. She holds a Professorship at the National University of Ireland, and Royal College of Surgeons, Ireland. She also holds an adjunct professorship at the National University of Singapore. She is a visiting Professor at Harvard Medical school. She obtained Ph.D. in Bio-Medical Physics in 1990 from University Malaya/University College London, and did her post-doctoral training between 1991-1995 in University College London, UK, McMaster University and University of Toronto, Ontario, Canada. She came to Singapore in 1995 and has been very active in biophotonics research in Singapore. She was a Principal Investigator at the Singapore National Cancer Centre and Singhealth between 1996-2009 heading clinical biophotonics research in cancer. In 2009, she accepted the Science Foundation Ireland, Stokes Chair Professorship at the National University of Ireland Galway and Royal College of Surgeons, Dublin Ireland. She returned to Singapore in 2012 to head bio-optical imaging in SBIC, A*STAR.

She is well recognized for her research by the International Biophotonics Community and regarded as a pioneer in the area of clinical applications of photomedicine in optical diagnostics and therapeutics in Singapore. In 2005, she was given the Singhealth research excellence award for her contribution to scientific research excellance in Singhealth in the area of clinical biophotonics for diagnostics and therapeutics of cancer. She has won numerous awards in recognition of her contribution to biophotonics in Singapore, Ireland and US. In 2011, the International society for photonics and optics SPIE conferred an award for her contribution as a woman in photonics.

Her current research interest is in nano-biophotonics and its applications in translational medicine. She has published over 300 scientific papers, 1 book, 9 book chapters and 10 patents. She has secured more then S$15 million in research grant as PI/Co-PI through various funding agencies in Singapore and Ireland. Her international standing in her field allows her to serve in numerous scientific advisory boards in the area of Photonics in Medicine. She currently serves in a select commitee in the EU research commission in Photonics 21 shaping and evaluating research in photonics for Life sciences till 2015.

Research Interests

 * Biophotonics in Medicine and Biology


 * Nano-Biophotonics


 * Photodiagnostics and Therapeutics

PI’s Laboratory Focus
The focus of her laboratory is to investigate novel optical strategies for cancer, metabolic medicine (diabetes and obesity)  and neurodegeneration   using the latest biophotonics and nanophotonics technologies.

The novel optical methods being developed are Surface Enhanced Raman Spectroscopy and Imaging (SERS) for bio-sensing and bio-imaging applications. SERS spectroscopy and imaging with nanophotonics is being investigated for  protein and biomarker sensing and tracking in cells and tissues both in-vivo and in vitro. In vivo cellular imaging systems using optical fluorescence lifetime imaging, optical coherence tomography (OCT), photo-acoustic and photothermal imaging are being investigated. Spectroscopy techniques are being combined with novel bio-chemo-synthetic optical probes and their formulations for preclinical and clinical applications.Tissue  spectroscopic methods based on  fluorescence, auto fluorescence, elastic scattering and NIR spectroscopy will be used for  preclinical and clinical based studies.

Publications (2008-2012)

 * 1) Kho KW, Dinish US, Anil Kumar and Olivo M. Frequency shifts in SERS Bio-sensing. ACS Nano. 2012 (in press)


 * 1) Douglas Goh, Tianxun Gong, US Dinish, Maiti KK, Fu CY, Yong KT and Olivo Malini. Pluronic Triblock coploymer encapsulated gold Nanorods as Biocompatible localized plasmon resonance enhanced scattering probes for imaging of cancer cells. Plasmonics. 2012 (in press)


 * 1) Dinish U. S, Chit Yaw Fu, Kiat Seng Soh, Ramaswamy Bhuvaneswari, Anil Kumar and Malini Olivo. Highly sensitive SERS detection of cancer proteins in low sample volume using hollow core photonic crystal fiber. Biosensors and Bioelectronics. 2012. 33(1):293-298.


 * 1) Deng S, Tjoa V, Fan HM, Tan HR, Sayle DC, Olivo M, Mhaisalkar SG, Wei J and Sow    CH. Reduced Graphene Oxide Conjugated Cu2O Nanowire Mesocrystals for High Performance NO2 Gas Sensor. J. Am Chem Soc. 2012 (in press)


 * 1) Malini Olivo, C.Y. Fu, Vijaya Raghavan, and Weber Kam On Lau. New Frontier in Hypericin-mediated Diagnosis of Cancer with Current Optical Technologies. Annals of Biomedical Engineering. 2012. 40(2):460-73
 * 1) Malini Olivo, C.Y. Fu, Vijaya Raghavan, and Weber Kam On Lau. New Frontier in Hypericin-mediated Diagnosis of Cancer with Current Optical Technologies. Annals of Biomedical Engineering. 2012. 40(2):460-73


 * 1) Maiti KK, DinishUS, Animesh S, Vendrell M, Soh KS, Park SJ, Olivo M and YT Chang. Multiplexed targeted in vivo cancer detection using sensitive near-infrared SERS nanotags. NanoToday. 2012 ( in press)
 * 1) Maiti KK, DinishUS, Animesh S, Vendrell M, Soh KS, Park SJ, Olivo M and YT Chang. Multiplexed targeted in vivo cancer detection using sensitive near-infrared SERS nanotags. NanoToday. 2012 ( in press)


 * 1) C.Y. Fu, K.W. Kho, U.S. Dinish, Z.Y. Koh and Malini Olivo. Increase in SERS Intensity with Enhanced Hierarchical Nanostructures by Bimetallic Deposition Approach. Journal of Raman Spectroscopy. 2012 (in press)
 * 1) C.Y. Fu, K.W. Kho, U.S. Dinish, Z.Y. Koh and Malini Olivo. Increase in SERS Intensity with Enhanced Hierarchical Nanostructures by Bimetallic Deposition Approach. Journal of Raman Spectroscopy. 2012 (in press)


 * 1) Kho KW, Shen ZX and Olivo MC. Generation of Ultra-Large SERS-active Hot-Spot Volumes by an array of 2D Nano-Superlenses. Analytical Chemistry. 2012. 84(2):908-916
 * 1) Kho KW, Shen ZX and Olivo MC. Generation of Ultra-Large SERS-active Hot-Spot Volumes by an array of 2D Nano-Superlenses. Analytical Chemistry. 2012. 84(2):908-916


 * 1) Ravi Kumar K, Dinish. U. S., Chit Yaw Fu, Gopalkrishna Hegde, Malini Olivo and Anand Asundi. Nano-Sphere Templated Metallic Grating Assisted enhanced Fluorescence. Journal of Fluorescence. 2012 (e pub in press)
 * 1) Ravi Kumar K, Dinish. U. S., Chit Yaw Fu, Gopalkrishna Hegde, Malini Olivo and Anand Asundi. Nano-Sphere Templated Metallic Grating Assisted enhanced Fluorescence. Journal of Fluorescence. 2012 (e pub in press)


 * 1) Fan Hai Ming and Olivo M. Magnetic nanorings and nanotubes for cancer detection and therapy. Book chapter In: Nanomedicine and Cancer, Eds: St. Bartholmew’s Hospital & King’s College London, ISBN 978-1-57808-727-3, Jan 2012.
 * 1) Fan Hai Ming and Olivo M. Magnetic nanorings and nanotubes for cancer detection and therapy. Book chapter In: Nanomedicine and Cancer, Eds: St. Bartholmew’s Hospital & King’s College London, ISBN 978-1-57808-727-3, Jan 2012.


 * 1) Samanta A, Maiti KK, Soh KS, Liao X, Vendrell M, Dinish US, Yun SW, Bhuvaneswari R, Kim H, Rautela S, Chung J, Olivo M and Chang YT. Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Imaging.  Angew Chem Int Ed Engl.  2011. 50(27):6089-6092
 * 1) Samanta A, Maiti KK, Soh KS, Liao X, Vendrell M, Dinish US, Yun SW, Bhuvaneswari R, Kim H, Rautela S, Chung J, Olivo M and Chang YT. Ultrasensitive Near-Infrared Raman Reporters for SERS-based in vivo Cancer Imaging.  Angew Chem Int Ed Engl.  2011. 50(27):6089-6092


 * 1) Olivo M, Bhuvaneswari R and Keogh I. Advances in bio-optical imaging for the diagnosis of early oral cancer. Pharmaceutics (Special issue: Molecular Imaging). 2011. 3(3): 354-378
 * 1) Olivo M, Bhuvaneswari R and Keogh I. Advances in bio-optical imaging for the diagnosis of early oral cancer. Pharmaceutics (Special issue: Molecular Imaging). 2011. 3(3): 354-378


 * 1) K.W. Kho, C.Y. Fu, U.S. Dinish and Malini Olivo. Clinical SERS: Are we there yet? Topical Issue - Review Clinical Biophotonics. J.  Biophotonics. 2011. 4(10):667-84
 * 1) K.W. Kho, C.Y. Fu, U.S. Dinish and Malini Olivo. Clinical SERS: Are we there yet? Topical Issue - Review Clinical Biophotonics. J.  Biophotonics. 2011. 4(10):667-84


 * 1) # Bhuvaneswari R and Olivo M. Photodynamic therapy in combination with anti-angiogenic approaches to treat bladder cancer.   Biosensors and Molecular Technologies for cancer diagnostics. Book chapter 18, In Tech eds  2012


 * 1) U.S. Dinish, C.Y. Fu, Agarwal Ajay and Malini Olivo. Development of highly reproducible nanogap SERS substrates: Comparative performance analysis and its application for glucose sensing. Biosensor and Bioelectronics. 2011. 26:1987-1992
 * 1) U.S. Dinish, C.Y. Fu, Agarwal Ajay and Malini Olivo. Development of highly reproducible nanogap SERS substrates: Comparative performance analysis and its application for glucose sensing. Biosensor and Bioelectronics. 2011. 26:1987-1992


 * 1) Mohamed Ali-Seyed, Ramaswamy Bhuvaneswari, Malini Olivo. Photolon™-Photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.  International Journal of Oncology. 2011. 39(4):821-31
 * 1) Mohamed Ali-Seyed, Ramaswamy Bhuvaneswari, Malini Olivo. Photolon™-Photosensitization induces apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes.  International Journal of Oncology. 2011. 39(4):821-31


 * 1) Waseem K Jerjes, Tahwinder Upile, Brian J Wong, Christian S Betz, Henricus J Sterenborg, Max J Witjes, Kristian Berg, Robert van Veen, Merrill A Biel, Adel K El-Naggar, Charles A Mosse, Malini Olivo, Rebecca Richards-Kortum, Dominic J Robinson, Jennifer Rosen, Arjun G Yodh, Catherine Kendall, Justus F Ilgner, Arjen Amelink, Vanderlei Bagnato, Hugh Barr, Lina Bolotine, Irving Bigio, Zhongping Chen, Lin-Ping Choo-Smith, Anil K D'Cruz, Ann Gillenwater, Andreas Leunig, Alexander J MacRobert and Gordon McKenzie. The future of medical diagnostics: review paper. Head & Neck Oncology. 2011. 3:38
 * 1) Waseem K Jerjes, Tahwinder Upile, Brian J Wong, Christian S Betz, Henricus J Sterenborg, Max J Witjes, Kristian Berg, Robert van Veen, Merrill A Biel, Adel K El-Naggar, Charles A Mosse, Malini Olivo, Rebecca Richards-Kortum, Dominic J Robinson, Jennifer Rosen, Arjun G Yodh, Catherine Kendall, Justus F Ilgner, Arjen Amelink, Vanderlei Bagnato, Hugh Barr, Lina Bolotine, Irving Bigio, Zhongping Chen, Lin-Ping Choo-Smith, Anil K D'Cruz, Ann Gillenwater, Andreas Leunig, Alexander J MacRobert and Gordon McKenzie. The future of medical diagnostics: review paper. Head & Neck Oncology. 2011. 3:38


 * 1) Tahwinder Upile; Waseem Jerjes; Henricus Sterenborg; Brian Wong; Adel El-Naggar; Justus Ilgner; Ann Sandison; Max Witjes; Merrill Biel; Robert van Veen; Zaid Hamdoon; Ann Gillenwater; Charles Mosse; Dominic Robinson; Christian Betz; Herbert Stepp; Lina Bolotine; Gordon McKenzie; Hugh Barr; Zhongping Chen; Kristian Berg; Anil D'Cruz; Holger Sudhoff; Nicholas Stone; Catherine Kendall; Sheila Fisher; Alexander MacRobert; Andreas Leunig; Olivo Malini; Rebecca Richards-Kortum; Khee Soo; Vanderlei Bagnato; Lin-Ping Choo-Smith; Katarina Svanberg; I Bing Tan; Brian Wilson; Herbert Wolfsen; Irving Bigio; Arjun Yodh; Colin Hopper. At the Frontiers of Surgery: Review. Head & Neck Oncology. 2011. 3:7
 * 1) Tahwinder Upile; Waseem Jerjes; Henricus Sterenborg; Brian Wong; Adel El-Naggar; Justus Ilgner; Ann Sandison; Max Witjes; Merrill Biel; Robert van Veen; Zaid Hamdoon; Ann Gillenwater; Charles Mosse; Dominic Robinson; Christian Betz; Herbert Stepp; Lina Bolotine; Gordon McKenzie; Hugh Barr; Zhongping Chen; Kristian Berg; Anil D'Cruz; Holger Sudhoff; Nicholas Stone; Catherine Kendall; Sheila Fisher; Alexander MacRobert; Andreas Leunig; Olivo Malini; Rebecca Richards-Kortum; Khee Soo; Vanderlei Bagnato; Lin-Ping Choo-Smith; Katarina Svanberg; I Bing Tan; Brian Wilson; Herbert Wolfsen; Irving Bigio; Arjun Yodh; Colin Hopper. At the Frontiers of Surgery: Review. Head & Neck Oncology. 2011. 3:7


 * 1) Ramaswamy Bhuvaneswari, Gan Yik Yuen, Soo Khee Chee and Malini Olivo. Anti-angiogenesis agents Avastin and Erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model. Lasers in Surgery and Medicine. 2011. 43(7):651-62
 * 1) Ramaswamy Bhuvaneswari, Gan Yik Yuen, Soo Khee Chee and Malini Olivo. Anti-angiogenesis agents Avastin and Erbitux enhance the efficacy of photodynamic therapy in a murine bladder tumor model. Lasers in Surgery and Medicine. 2011. 43(7):651-62


 * 1) # # Kho KW, Shen ZX and Olivo MC. Sub-micron Free-standing Metal Slabs with Dielectric Nano-voids of Arbitrary Shapes Embedded beneath Atomically-Smooth Surface. Opt. Exp. 2011. 19(11):10518-10535


 * 1) Kho KW, Shen ZX and Olivo MC. Broadband High-resolution Imaging via a 2D Plasmonic Super-lens Constructed with an Embedded Oblate Nanocavity. Highlighted in Nature Photonics. 2011. 5:194
 * 1) Kho KW, Shen ZX and Olivo MC. Broadband High-resolution Imaging via a 2D Plasmonic Super-lens Constructed with an Embedded Oblate Nanocavity. Highlighted in Nature Photonics. 2011. 5:194


 * 1) Xiaojing Mu, Winston Sun, Hanhua Feng, Aibin Yu, Kelvin Wei Sheng Chen, Chit Yaw Fu, and Malini Olivo. MEMS Micromirror Integrated Endoscopic Probe for Optical Coherence Tomography Bioimaging. Sensors and Actuators. 2011. 168:202-212
 * 1) Xiaojing Mu, Winston Sun, Hanhua Feng, Aibin Yu, Kelvin Wei Sheng Chen, Chit Yaw Fu, and Malini Olivo. MEMS Micromirror Integrated Endoscopic Probe for Optical Coherence Tomography Bioimaging. Sensors and Actuators. 2011. 168:202-212


 * 1) Kiang Wei Kho, Shen ZeXiang and Olivo Malini. Hyper-spectral confocal nano-imaging with a 2D super-lens. Optics Express. 2011.19(3):2502-2518
 * 1) Kiang Wei Kho, Shen ZeXiang and Olivo Malini. Hyper-spectral confocal nano-imaging with a 2D super-lens. Optics Express. 2011.19(3):2502-2518


 * 1) Olivo M, Bhuvaneswari R and Keogh I. Early detection of oral cancer using bio-optical imaging technologies. Book Chapter in “Biosensors and biodetection technologies for cancer detection, diagnostics and research” Editors: NIH; Rasooly A and Herold K.(In press 2011)
 * 1) Olivo M, Bhuvaneswari R and Keogh I. Early detection of oral cancer using bio-optical imaging technologies. Book Chapter in “Biosensors and biodetection technologies for cancer detection, diagnostics and research” Editors: NIH; Rasooly A and Herold K.(In press 2011)


 * 1) Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Malini Olivo and Young-Tae Chang. Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters. Chem Comm. 2011. 47:3514-3516
 * 1) Kaustabh Kumar Maiti, Animesh Samanta, Marc Vendrell, Kiat-Seng Soh, Malini Olivo and Young-Tae Chang. Multiplex cancer cell detection by SERS nanotags with cyanine and triphenylmethine Raman reporters. Chem Comm. 2011. 47:3514-3516


 * 1) PSP Thong, M Olivo, HS Seah, F Lin, K Qian and KC Soo. Hypericin fluorescence imaging of oral cancer: From endoscopy to real-time 3-dimensional endomicroscopy. Journal of Medical Imaging and Health Informatics. 2011. 1:1-5
 * 1) PSP Thong, M Olivo, HS Seah, F Lin, K Qian and KC Soo. Hypericin fluorescence imaging of oral cancer: From endoscopy to real-time 3-dimensional endomicroscopy. Journal of Medical Imaging and Health Informatics. 2011. 1:1-5


 * 1) Lee LS, Thong PS, Olivo M, Chin WW, Ramaswamy B, Kho KW, Lim PL and Lau WK. Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy-A potential bladder sparing option for high risk non-muscle invasive bladder cancer. Photodiagnosis Photodyn Ther. 2010. 7(4):213-220
 * 1) Lee LS, Thong PS, Olivo M, Chin WW, Ramaswamy B, Kho KW, Lim PL and Lau WK. Chlorin e6-polyvinylpyrrolidone mediated photodynamic therapy-A potential bladder sparing option for high risk non-muscle invasive bladder cancer. Photodiagnosis Photodyn Ther. 2010. 7(4):213-220


 * 1) Olivo, M. Optical imaging in biomedicine. in Townsend, D. (ed.), Medical Imaging: Imaging Techniques for Pre-clinical and Clinical Applications. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London. 2010. (online at http://hstalks.com/?t=BL1032775-Olivo)
 * 1) Olivo, M. Optical imaging in biomedicine. in Townsend, D. (ed.), Medical Imaging: Imaging Techniques for Pre-clinical and Clinical Applications. The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London. 2010. (online at http://hstalks.com/?t=BL1032775-Olivo)


 * 1) H. M. Fan, Malini Olivo, B. Shuter, R. Bhuvaneswari, J. B. Yi, H. R. Tan, G. C. Xing, CT Ng, L. Liu, S. S. Lucky, Bay BH and J. Ding. Quantum. Dot Capped Magnetite Nanoring as high performance nanoprobe for Multiphoton Fluorescence and Magnetic Resonance Imaging. J Am Chem Soc. 2010. 132(42):14803-14811
 * 1) H. M. Fan, Malini Olivo, B. Shuter, R. Bhuvaneswari, J. B. Yi, H. R. Tan, G. C. Xing, CT Ng, L. Liu, S. S. Lucky, Bay BH and J. Ding. Quantum. Dot Capped Magnetite Nanoring as high performance nanoprobe for Multiphoton Fluorescence and Magnetic Resonance Imaging. J Am Chem Soc. 2010. 132(42):14803-14811


 * 1) Maiti KK, Dinish US, Fu CY, Jae-Jun Lee, Soh Kiat Seng, Bhuvana Ramaswamy, Olivo M* and Chang YT*. Development of Biocompatible SERS Nanotag with Increased Stability by Chemisorption of Reporter Molecule for in vivo Cancer Detection. Biosensors Bioelectron. 2010. 26(2):398-403
 * 1) Maiti KK, Dinish US, Fu CY, Jae-Jun Lee, Soh Kiat Seng, Bhuvana Ramaswamy, Olivo M* and Chang YT*. Development of Biocompatible SERS Nanotag with Increased Stability by Chemisorption of Reporter Molecule for in vivo Cancer Detection. Biosensors Bioelectron. 2010. 26(2):398-403


 * 1) Vasudevan S, Chen GC, Andika M, Agarwal S, Chen P and Olivo M. Dynamic quantitative photothermal monitoring of cell death of individual human red blood cells upon glucose depletion. J Biomed Opt. 2010. 15(5):057001
 * 1) Vasudevan S, Chen GC, Andika M, Agarwal S, Chen P and Olivo M. Dynamic quantitative photothermal monitoring of cell death of individual human red blood cells upon glucose depletion. J Biomed Opt. 2010. 15(5):057001


 * 1) Malini Olivo, Sasidharan Swarnalatha Lucky, Kent Mancer and Weber Kam On Lau. Role of cell-adhesion molecules in the differential accumulation of hypericin in photodynamic diagnosis of bladder cancer. Urologic Oncology: Seminars and Original Investigations. 2010 (In Press)
 * 1) Malini Olivo, Sasidharan Swarnalatha Lucky, Kent Mancer and Weber Kam On Lau. Role of cell-adhesion molecules in the differential accumulation of hypericin in photodynamic diagnosis of bladder cancer. Urologic Oncology: Seminars and Original Investigations. 2010 (In Press)


 * 1) Hui Dong, Yandong Gong and Malini Olivo. Measurement of stokes parameters of terahertz radiation in terahertz timedomain spectroscopy.  Microwave and Optical Technology Letters. 2010. 52(10):2319-24
 * 1) Hui Dong, Yandong Gong and Malini Olivo. Measurement of stokes parameters of terahertz radiation in terahertz timedomain spectroscopy.  Microwave and Optical Technology Letters. 2010. 52(10):2319-24


 * 1) Chin WW, Thoniyot P, Heng PWS and Olivo M. Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization. Eur J Pharm Biopharm. 2010. 76(2):245-52
 * 1) Chin WW, Thoniyot P, Heng PWS and Olivo M. Effect of polyvinylpyrrolidone on the interaction of chlorin e6 with plasma proteins and its subcellular localization. Eur J Pharm Biopharm. 2010. 76(2):245-52


 * 1) Han W, Chuang KH, Chang YT, Olivo M, Velan SS, Bhakoo K, Townsend D and Radda GK. Imaging metabolic syndrome. EMBO molecular medicine. 2010. 2(6):196-210
 * 1) Han W, Chuang KH, Chang YT, Olivo M, Velan SS, Bhakoo K, Townsend D and Radda GK. Imaging metabolic syndrome. EMBO molecular medicine. 2010. 2(6):196-210


 * 1) Cho SJ, Ahn YH, Maiti KK, Dinish US, Fu CY, Thoniyot P, Olivo M* and Chang YT*. Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Chem Comm. (Camb). 2010. 46(5):722-4
 * 1) Cho SJ, Ahn YH, Maiti KK, Dinish US, Fu CY, Thoniyot P, Olivo M* and Chang YT*. Combinatorial synthesis of a triphenylmethine library and their application in the development of surface enhanced Raman scattering (SERS) probes. Chem Comm. (Camb). 2010. 46(5):722-4


 * 1) Y Xu, M F Wang, C S Premachandran, K W S Chen, N Chen and M Olivo. Platinum microheater integrated silicon optical bench assembly for endoscopic optical coherence tomography. J of Micromechanics and Microengineering. 2010. 20(015008):1-8
 * 1) Y Xu, M F Wang, C S Premachandran, K W S Chen, N Chen and M Olivo. Platinum microheater integrated silicon optical bench assembly for endoscopic optical coherence tomography. J of Micromechanics and Microengineering. 2010. 20(015008):1-8


 * 1) Malini Olivo, Ramaswamy Bhuvaneswari, Sasidharan Swarnalatha Lucky, Nagamani Dendukuri and Patricia Soo-Ping Thong. Targeted Therapy of Cancer using Photodynamic Therapy in Combination with Multi-faceted Anti-tumor Modalities. Pharmaceuticals. 2010. 3(5):1507-1529
 * 1) Malini Olivo, Ramaswamy Bhuvaneswari, Sasidharan Swarnalatha Lucky, Nagamani Dendukuri and Patricia Soo-Ping Thong. Targeted Therapy of Cancer using Photodynamic Therapy in Combination with Multi-faceted Anti-tumor Modalities. Pharmaceuticals. 2010. 3(5):1507-1529


 * 1) Bhuvaneswari R, Thong PSP, Gan YY, Soo KC and Olivo M. Evaluation of photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy. J Biomed Opt. 2010. 15(1):011114
 * 1) Bhuvaneswari R, Thong PSP, Gan YY, Soo KC and Olivo M. Evaluation of photodynamic therapy in combination with angiogenesis inhibitor bevacizumab using in vivo fluorescence confocal endomicroscopy. J Biomed Opt. 2010. 15(1):011114


 * 1) Hai-Ming Fan, Jia-Bao Yi, Yi Yang, Kiang-Wei Kho, Hui-Ru Tan, Ze-Xiang Shen, Jun Ding, Xiao-Wei Sun, Yuan-Ping Feng and Malini Carolene Olivo. Single-Crystalline MFe2O4 Nanotubes/Nanorings Synthesized by Thermal Transformation Process for Biological Applications. ACS Nano. 2009. 3(9): 2798–2808
 * 1) Hai-Ming Fan, Jia-Bao Yi, Yi Yang, Kiang-Wei Kho, Hui-Ru Tan, Ze-Xiang Shen, Jun Ding, Xiao-Wei Sun, Yuan-Ping Feng and Malini Carolene Olivo. Single-Crystalline MFe2O4 Nanotubes/Nanorings Synthesized by Thermal Transformation Process for Biological Applications. ACS Nano. 2009. 3(9): 2798–2808


 * 1) Dong H, Gong YD, Paulose V, Shum P and Olivo M. Optimum input states of polarization for Mueller matrix measurement in a system having finite polarization-dependent loss or gain. Opt Express. 2009. 17(25):23044-57
 * 1) Dong H, Gong YD, Paulose V, Shum P and Olivo M. Optimum input states of polarization for Mueller matrix measurement in a system having finite polarization-dependent loss or gain. Opt Express. 2009. 17(25):23044-57


 * 1) Bhuvaneswari R, Gan YY, Soo KC and Olivo M. Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer. 2009. 8(1):94
 * 1) Bhuvaneswari R, Gan YY, Soo KC and Olivo M. Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer. 2009. 8(1):94


 * 1) Malini Olivo, Patricia S.P. Thong,William W.L. Chin, Ramaswamy Bhuvaneswari, Kent Mancer and Khee-Chee Soo. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. Br. J. Cancer. 2009. 101(9):1580-4
 * 1) Malini Olivo, Patricia S.P. Thong,William W.L. Chin, Ramaswamy Bhuvaneswari, Kent Mancer and Khee-Chee Soo. Clinical application of fluorescence endoscopic imaging using hypericin for the diagnosis of human oral cavity lesions. Br. J. Cancer. 2009. 101(9):1580-4


 * 1) Feng Lin and Malini Olivo. The State-of-the-art Technologies for Medical and Biological Imaging, Guest Editors’ Comments. J. Sign Process Syst.  2009. 54:1–6
 * 1) Feng Lin and Malini Olivo. The State-of-the-art Technologies for Medical and Biological Imaging, Guest Editors’ Comments. J. Sign Process Syst.  2009. 54:1–6


 * 1) H. Dong, YD Gong, Varghese Paulose, P Shum and Malini Olivo. Effect of input states of polarization on the measurement error of Mueller matrix in a system having small polarization-dependent loss or gain. Optics Express. 2009. 17(15):13017-30
 * 1) H. Dong, YD Gong, Varghese Paulose, P Shum and Malini Olivo. Effect of input states of polarization on the measurement error of Mueller matrix in a system having small polarization-dependent loss or gain. Optics Express. 2009. 17(15):13017-30


 * 1) C. S. Premachandran, Ahmad Khairyanto, Kelvin Chen Wei Sheng, Janak Singh, Jason Teo, Xu Yingshun, Chen Nanguang, Colin Sheppard and Malini Olivo. Design, fabrication, and assembly of an optical biosensor probe package for OCT (Optical Coherence Tomography) application. IEEE Transaction on Advanced Packaging. 2009. 32(2):417-422
 * 1) C. S. Premachandran, Ahmad Khairyanto, Kelvin Chen Wei Sheng, Janak Singh, Jason Teo, Xu Yingshun, Chen Nanguang, Colin Sheppard and Malini Olivo. Design, fabrication, and assembly of an optical biosensor probe package for OCT (Optical Coherence Tomography) application. IEEE Transaction on Advanced Packaging. 2009. 32(2):417-422


 * 1) Tahwinder Upile, Waseem Jerjes, Henricus JCM Sterenborg, Adel K El-Naggar, Ann Sandison, Max JH Witjes, Merrill A Biel, Irving Bigio, Brian JF Wong, Ann Gillenwater, Alexander J MacRobert, Dominic J Robinson, Christian S Betz, Herbert Stepp, Lina Bolotine, Gordon McKenzie, Charles Alexander Mosse, Hugh Barr, Zhongping Chen, Kristian Berg, Anil K D'Cruz, Nicholas Stone, Catherine Kendall, Sheila Fisher, Andreas Leunig, Malini Olivo, Rebecca Richards-Kortum, Khee Chee Soo, Vanderlei Bagnato, Lin-Ping Choo-Smith, Katarina Svanberg, I Bing Tan, Brian C Wilson, Herbert Wolfsen, Arjun G Yodh  and Colin Hopper. Meeting Report - Head & neck optical diagnostics: vision of the future of surgery. Head & Neck Oncology. 2009. 1:25
 * 1) Tahwinder Upile, Waseem Jerjes, Henricus JCM Sterenborg, Adel K El-Naggar, Ann Sandison, Max JH Witjes, Merrill A Biel, Irving Bigio, Brian JF Wong, Ann Gillenwater, Alexander J MacRobert, Dominic J Robinson, Christian S Betz, Herbert Stepp, Lina Bolotine, Gordon McKenzie, Charles Alexander Mosse, Hugh Barr, Zhongping Chen, Kristian Berg, Anil K D'Cruz, Nicholas Stone, Catherine Kendall, Sheila Fisher, Andreas Leunig, Malini Olivo, Rebecca Richards-Kortum, Khee Chee Soo, Vanderlei Bagnato, Lin-Ping Choo-Smith, Katarina Svanberg, I Bing Tan, Brian C Wilson, Herbert Wolfsen, Arjun G Yodh  and Colin Hopper. Meeting Report - Head & neck optical diagnostics: vision of the future of surgery. Head & Neck Oncology. 2009. 1:25


 * 1) Bhuvaneswari R, Gan YY, Soo KC and Olivo M. The effect of photodynamic therapy on tumor angiogenesis. Cellular and molecular life sciences. 2009. 66(14):2275-2283
 * 1) Bhuvaneswari R, Gan YY, Soo KC and Olivo M. The effect of photodynamic therapy on tumor angiogenesis. Cellular and molecular life sciences. 2009. 66(14):2275-2283


 * 1) # 49.James Chen Yong Kah, Tzu Hao Chow, Beng Koon Ng, Sirajudeen Gulam Razul, Malini Olivo and Colin James Richard Sheppard. Concentration dependence of gold nanoshells on the enhancement of optical coherence tomography images: A quantitative study. Applied Optics. 2009. 48(10):D96-D108


 * 1) Kah JC, Olivo M, Chow TH, Song KS, Koh KZ, Mhaisalkar S and Sheppard CJ. Control of optical contrast using gold nanoshells for optical coherence tomography imaging of mouse xenograft tumor model in vivo. J Biomed Opt. 2009. 14(5):054015
 * 1) Kah JC, Olivo M, Chow TH, Song KS, Koh KZ, Mhaisalkar S and Sheppard CJ. Control of optical contrast using gold nanoshells for optical coherence tomography imaging of mouse xenograft tumor model in vivo. J Biomed Opt. 2009. 14(5):054015


 * 1) Liu J, Saw CL, Olivo M, Sudhaharan T, Ahmed S, Heng PW and Wohland T. Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques. J of Biomedical Optics. 2009. 14(1):014003
 * 1) Liu J, Saw CL, Olivo M, Sudhaharan T, Ahmed S, Heng PW and Wohland T. Study of interaction of hypericin and its pharmaceutical preparation by fluorescence techniques. J of Biomedical Optics. 2009. 14(1):014003


 * 1) Feng Lin, Malini Olivo and Sun-Yuan Kung Ed. BOOK: Biomedical Imaging. Published by Springer US. 2009
 * 1) Feng Lin, Malini Olivo and Sun-Yuan Kung Ed. BOOK: Biomedical Imaging. Published by Springer US. 2009


 * 1) Chin WW, Thong PSP, Bhuvaneswari R, Soo KC, Heng PW and Olivo M. In-vivo optical detection of cancer using clorin e6-polyvinylpyrrolidone induced fluorescence imaging and spectroscopy. BMC Medical Imaging. 2009. 9(1):1
 * 1) Chin WW, Thong PSP, Bhuvaneswari R, Soo KC, Heng PW and Olivo M. In-vivo optical detection of cancer using clorin e6-polyvinylpyrrolidone induced fluorescence imaging and spectroscopy. BMC Medical Imaging. 2009. 9(1):1


 * 1) Lee Sing Cheong, Feng Lin, Hock Soon Seah, Kemao Qian, Feng Zhao, Patricia S. P. Thong, Khee Chee Soo, Malini Olivo and Sun-Yuan Kung. Embedded Computing for Fluorescence Confocal Endomicroscopy Imaging. Journal of Signal Processing Systems. 2009. 55:217-228
 * 1) Lee Sing Cheong, Feng Lin, Hock Soon Seah, Kemao Qian, Feng Zhao, Patricia S. P. Thong, Khee Chee Soo, Malini Olivo and Sun-Yuan Kung. Embedded Computing for Fluorescence Confocal Endomicroscopy Imaging. Journal of Signal Processing Systems. 2009. 55:217-228


 * 1) Y Xu, J Singh, C S Premachandran, A Khairyanto, KW S Chen, N Chen, C J R Sheppard and Olivo M. Design and development of a 3D scanning MEMS OCT probe using a novel SiOB package assembly. J of Micromechanics and Microengineering. 2008.18(125005):1-8
 * 1) Y Xu, J Singh, C S Premachandran, A Khairyanto, KW S Chen, N Chen, C J R Sheppard and Olivo M. Design and development of a 3D scanning MEMS OCT probe using a novel SiOB package assembly. J of Micromechanics and Microengineering. 2008.18(125005):1-8


 * 1) J Singh, J H S Teo, Y Xu, C S Premachandran, N Chen, R Kotlanka, M Olivo and C J R Sheppard. A two axes scanning SOI MEMS micromirror for endoscopic bioimaging. J of Micromechanics and Microengineering. 2008. 18(025001):1-9
 * 1) J Singh, J H S Teo, Y Xu, C S Premachandran, N Chen, R Kotlanka, M Olivo and C J R Sheppard. A two axes scanning SOI MEMS micromirror for endoscopic bioimaging. J of Micromechanics and Microengineering. 2008. 18(025001):1-9


 * 1) Kah JC, Wan RC, Wong KY, Mhaisalkar S, Sheppard CJ and Olivo M. Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study. Lasers Surg Med. 2008. 40(8): 584-9
 * 1) Kah JC, Wan RC, Wong KY, Mhaisalkar S, Sheppard CJ and Olivo M. Combinatorial treatment of photothermal therapy using gold nanoshells with conventional photodynamic therapy to improve treatment efficacy: an in vitro study. Lasers Surg Med. 2008. 40(8): 584-9


 * 1) Kah JC, Wong KY, Neoh KG, Song JH, Fu JW, Mhaisalkar S, Olivo M and Sheppard CJ. Critical parameters in the pegylation of gold nanoshells for biomedical applications: An in vitro macrophage study. J Drug Target. 2008. 17(3):181-93
 * 1) Kah JC, Wong KY, Neoh KG, Song JH, Fu JW, Mhaisalkar S, Olivo M and Sheppard CJ. Critical parameters in the pegylation of gold nanoshells for biomedical applications: An in vitro macrophage study. J Drug Target. 2008. 17(3):181-93


 * 1) Kho KW, Qing KZ, Shen ZX, Ahmad IB, Lim SS, Mhaisalkar S, White TJ, Watt F, Soo KC and Olivo M. Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis. J. of Biomedical Optics. 2008.13(5):054026
 * 1) Kho KW, Qing KZ, Shen ZX, Ahmad IB, Lim SS, Mhaisalkar S, White TJ, Watt F, Soo KC and Olivo M. Polymer-based microfluidics with surface-enhanced Raman-spectroscopy-active periodic metal nanostructures for biofluid analysis. J. of Biomedical Optics. 2008.13(5):054026


 * 1) James Chen Yong Kah, Weber Kam On Lau, Phuay Hoon Tan, Colin James Richard Sheppard and Malini Olivo. Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ. J. Biomed Opt. 2008. 13(5):054022
 * 1) James Chen Yong Kah, Weber Kam On Lau, Phuay Hoon Tan, Colin James Richard Sheppard and Malini Olivo. Endoscopic image analysis of photosensitizer fluorescence as a promising noninvasive approach for pathological grading of bladder cancer in situ. J. Biomed Opt. 2008. 13(5):054022


 * 1) Kah JC, Phonthammachai N, Wan RCY, Song J, White T, Mhaisalkar S, Ahmad I, Sheppard C, Olivo M. Synthesis of gold nanoshells using precursor seed particles prepared from a deposition-precipitation process. Gold Bulletin. 2008. 41(1):23-36
 * 1) Kah JC, Phonthammachai N, Wan RCY, Song J, White T, Mhaisalkar S, Ahmad I, Sheppard C, Olivo M. Synthesis of gold nanoshells using precursor seed particles prepared from a deposition-precipitation process. Gold Bulletin. 2008. 41(1):23-36


 * 1) Napphawan Phonthammachai, James CY Kah, Guo Jun, Colin JR Sheppard, Malini C Olivo, Subhodh G Mhaisalkar and Timothy J White. Synthesis of Contiguous Silica-Gold Core-Shell Structures: Critical parameters and processes. Langmuir. 2008. 24(9):5109-5112
 * 1) Napphawan Phonthammachai, James CY Kah, Guo Jun, Colin JR Sheppard, Malini C Olivo, Subhodh G Mhaisalkar and Timothy J White. Synthesis of Contiguous Silica-Gold Core-Shell Structures: Critical parameters and processes. Langmuir. 2008. 24(9):5109-5112


 * 1) Ramaswamy Bhuvaneswari, Yik Yuen Gan, Sasidharan Swarnalatha Lucky, William Wei Lim Chin, Mohamed Ali-Seyed, Khee Chee Soo and Malini Olivo. Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. Molecular Cancer. 2008. 7(1):56
 * 1) Ramaswamy Bhuvaneswari, Yik Yuen Gan, Sasidharan Swarnalatha Lucky, William Wei Lim Chin, Mohamed Ali-Seyed, Khee Chee Soo and Malini Olivo. Molecular profiling of angiogenesis in hypericin mediated photodynamic therapy. Molecular Cancer. 2008. 7(1):56


 * 1) William Wei Lim Chin, Paul Wan Sia Heng, Pei Li Lim, Weber Kam On Lau and Malini Olivo. Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model. Journal of Biophotonics. 2008. 1(5):395–407
 * 1) William Wei Lim Chin, Paul Wan Sia Heng, Pei Li Lim, Weber Kam On Lau and Malini Olivo. Membrane transport enhancement of chlorin e6-polyvinylpyrrolidone and its photodynamic efficacy on the chick chorioallantoic model. Journal of Biophotonics. 2008. 1(5):395–407


 * 1) Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW and Soo KC. Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. Journal of Environmental Pathology, Toxicology and Oncology. 2008. 27(1):35-42
 * 1) Thong PS, Olivo M, Kho KW, Bhuvaneswari R, Chin WW, Ong KW and Soo KC. Immune response against angiosarcoma following lower fluence rate clinical photodynamic therapy. Journal of Environmental Pathology, Toxicology and Oncology. 2008. 27(1):35-42


 * 1) Saw CL, Heng PW and Olivo M. Potentiation of the Photodynamic Action of Hypericin. Journal of Environmental Pathology, Toxicology and Oncology. 2008. 27(1): 23-33
 * 1) Saw CL, Heng PW and Olivo M. Potentiation of the Photodynamic Action of Hypericin. Journal of Environmental Pathology, Toxicology and Oncology. 2008. 27(1): 23-33


 * 1) James KC, Olivo MC, Caroline Lee SG and Sheppard CJR. Molecular contrast of EGFR expression using gold nanoparticles as a reflectance-based imaging probe. Mol Cell Probes. 2008. 22(1):14-23
 * 1) James KC, Olivo MC, Caroline Lee SG and Sheppard CJR. Molecular contrast of EGFR expression using gold nanoparticles as a reflectance-based imaging probe. Mol Cell Probes. 2008. 22(1):14-23


 * 1) William Wei Lim Chin, Paul Wan Sia Heng, Patricia Soo Ping Thong,  Ramaswamy Bhuvaneswari, Werner Hirt, Sebastian Kuenzel, Khee Chee Soo and Malini Olivo. Improved formulation of photosensitizer chlorin e6–polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur. J. Pharm. Biopharm. 2008. 69(3):1083-93
 * 1) William Wei Lim Chin, Paul Wan Sia Heng, Patricia Soo Ping Thong,  Ramaswamy Bhuvaneswari, Werner Hirt, Sebastian Kuenzel, Khee Chee Soo and Malini Olivo. Improved formulation of photosensitizer chlorin e6–polyvinylpyrrolidone for fluorescence diagnostic imaging and photodynamic therapy of human cancer. Eur. J. Pharm. Biopharm. 2008. 69(3):1083-93