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Frog Virus 3

Frog virus 3(FV3) is a large dsDNA belonging to Ranaviruses of the family Iridoviridae. Depending on the host immune response, infection with FV3 may or may not lead to mortality.

History Frog virus 3(FV3) was isolated in 1966 from the leopard frog, Rana pipiens. Additional isolates similar to FV3 were made from cultured normal adult frog kidney cells and liver homogenates of normal or tumor-bearing frogs. Nucleic acid hybridization and restriction endonuclease analyses of DNA from several of the viruses as well as serological comparisons suggest that they probably represent different strains of the same prototype virus. Any host infected with FV3 experience symptoms such as edema, hemorrhage, and necrosis of lymphoid tissue, hematopoietic tissue, liver, spleen, and renal tubules. The mortality rate of free-ranging amphibians are >90%. Susceptibility to FV3 varies by species and life cycle. The way the amphibian immune system responds to FV3 is not currently known as of November 17, 2022.