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=Burkhard Rost= Professor Burkhard Rost, is a scientist currently heading the Unit for Computational Biology &amp; Bioinformatics at the Department of Informatics of the Technical University of Munich. Rost chairs the Study Section Bioinformatics Munich involving the TUM (Technical University of Munich) and the LMU (Ludwig Maximilian University of Munich) in Munich. Since 2007 Rost is the President of [www.iscb.org ISCB], the International Society for Computational Biology.

Career
Burkhard Rost originally started his scientific career as theoretical physicist. After studying physics at the University of Giessen and physics, history, philosophy, and psychology at the University of Heidelberg, Professor Rost received his doctorate at the European Molecular Biology Laboratory (EMBL) in 1994. Following research internships at EMBL and the European Bioinformatics Institute in Cambridge (UK), in 1998, he became assistant a professor at the Department of Biochemistry and Molecular Biophysics in the College of Surgeons and Physicians of the CU Medical Center of Columbia University in the City of New York. In 2000, he became associate professor at Columbia University and in 2009 he accepted an appointment to the Chair of Bioinformatics at the Technical University of Munich. He is a member of the New York Academy of Sciences and has been President of ISCB, the International Society for Computational Biology since 2007. He has authored over 200 scientific publications with an ISI Hirsch index of 52 (2011).

Contributions to Computational Biology
Professor Rost research has focused on combining Machine Learning and evolutionary information to predict aspects of critical importance to advance our understanding of evolution, protein structure and protein function. Examples of research carried out in his lab includes the prediction of enzymatic activity (ECGO), interaction partners (ISIS, DISIS, PiNAT), subcellular localization (LOCtree, LOCnet, PredictNLS), functional effects of point mutations/SNPs (SNAP), disordered regions (MD, NORSnet, Ucon), membrane spanning segments (PROF/PHDhtm), secondary structure (PROF/PHD, RePROF, DSSPcont), solvent accessibility (PROF/PHD, RePROF), internal residue-residue contacts (PROFcon) and the clustering of proteins into families (CHOP).

The current focus of the [www.rostlab.org Rostlab] is on predicting the effects of individual mutations mostly on the level of non-synonymous changes in coding regions, i.e. single nucleotide changes (or Single Nucleotide Polymorphisms that alter the amino acid sequence.

His group has been dedicated to making their tools available online as demonstrated through the first internet server for protein structure prediction and sequence analysis, [www.predictprotein.org PredictProtein], that was launched in 1992, and has been continuously in service ever since.

ISCB
Rost has been President of the professional international organization in computational biology and bioinformatics, the International Society for Computational Biology (ISCB) since 2007. He will continue to serve until 2014.

Conferences
Rost has co-chaired the largest annual meeting in computational biology ISMB, Intelligent Systems for Molecular Biology, in 2007 (Vienna), 2008 (Toronto), 2011 (Vienna), 2012 (Long Beach). He has initiated and been involved in the organization of several series of international conferences outside the usual northern hemisphere, namely the ISCB Africa (2010: Bamako, Mali; 2011: Cape Town, South Africa; 2013: Tunis, Tunisia) in cooperation with the [www.asbcb.org African Society for Computational Biology and Bioinformatics ASBCB], the ISCB Latin America (2010: Montevideo, Uruguay; 2012: Santiago de Chile, Chile; 2014: Rio de Janeiro, Brazil), and most recently the ISCB Asia (2011: Kuala Lumpur, Malaysia; 2012: Shen Zhen, China).

Rost has also been a co-organizer of the CASP Critical Assessment of protein Structure Prediction meetings from 2002-2008 (CASP4-CASP8).

Noteworthy Achievements

 * Professorship of the Alexander von Humboldt Foundation in 2009.

Publications
Excerpt from full publication list; direct link to more complete list below under PubMed.


 * E Kloppmann, M Punta and B Rost (2012) Structural genomics plucks high-hanging membrane proteins. Curr Opin Struct Biol May 21, 601-602.
 * T Hopf, LJ Colwell, R Sheridan, B Rost, C Sander and DS Marks (2012) Three-dimensional structures of membrane proteins from genomic sequencing. Cell May 9 online.
 * C Schaefer, A Meier, B Rost and Y Bromberg (2012) SNPdbe: Constructing an nsSNP functional impacts database. Bioinformatics 28, 601-602.


 * A Schlessinger, C Schaefer, E Vicedo, M Schmidberger, M Punta, B Rost (2011) Protein disorder - a breakthrough invention of evolution? Curr Opin Struct Biol, 21, 412-418.
 * RH Lathrop & B Rost (2011) ISCB Public Policy Statement on Open Access to Scientific and Technical Research Literature. PLoS Comput Biol 7, e1002014.
 * S Rastogi & B Rost (2011) LocDB: experimental annotations of localization for Homo sapiens and Arabidopsis thaliana. NAR 39, D230-234.


 * YH Chen, L Hu, M Punta, R Bruni, B Hillerich, B Kloss, B Rost, J Love, SA Siegelbaum & WA Hendrickson (2010) Homologue structure of the SLAC1 anion channel for closing stomata in leaves. Nature 28, 1074-1080.
 * C Schaefer, A Schlessinger & B Rost (2010) Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be. Bioionformatics 26, 625-631.


 * M Punta, J Love, S Handelman, JF Hunt, L Shapiro, WA Hendrickson & B Rost (2009) Structural genomics target selection for the New York consortium on membrane protein structure. J Structural & Functional Genomics 10, 779-784.
 * Y Bromberg, J Overton, RL Leibel & B Rost (2009) In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J 23, 3059-3069.
 * Y Bromberg & B Rost (2009) Correlating protein function and stability through the analysis of single amino acid substitutions. BMC Bioinformatics 10 Suppl 8, S8.
 * A Kernytsky & B Rost (2009) Using genetic algorithms to select most predictive protein features. Proteins 75, 75-88.
 * Y Bromberg, G Yachdav, Y Ofran, R Schneider & B Rost (2009) New in protein structure and function annotation: hotspots, single nucleotide polymorphisms and the Deep Web. Curr Opin Drug Discov Devel 12, 408-419.
 * A Schlessinger, M Punta, G Yachdav, L Kajan & B Rost (2009) Improved disorder prediction by combination of orthogonal approaches. PLoS ONE 4, doi:10.1371/journal.pone.0004433.


 * T-T Soong, KO Wrzeszczynski & B Rost (2008) Physical protein-protein interactions predicted from microarrays. Bioinformatics 15, 2608-2614.
 * Y Bromberg & B Rost (2008) SNAP predicts effect of mutations on protein function. Bioinformatics 24, 2397-2398.
 * Y Ofran, A Schlessinger & B Rost (2008) Automated Identification of Complementarity Determining Regions (CDRs) reveals peculiar characteristics of CDRs and B cell epitopes. J Immunology 181, 6230-6235.
 * D Przybylski & B Rost (2008) Powerful fusion: PSI-BLAST and consensus sequences. Proteins 24, 1987-1993.
 * Y Bromberg & B Rost (2008) Comprehensive in silico mutagenesis highlights functionally important residues in proteins. Bioinformatics (ECCB Proceedings) 24, i207-i212.
 * A Schlessinger, M Punta & B Rost (2007) Natively unstructured regions in proteins identified from contact predictions. Bioinformatics 23, 2376-2384.


 * J Liu, GT Montelione & B Rost (2007) Novel leverage of structural genomics. Nature Biotech 25,849-851.
 * A Schlessinger, J Liu & B Rost (2007) Natively unstructured loops differ from other loops. PLoS Comp Biol 3, e140.
 * Y Ofran, V Mysore & B Rost (2007) Prediction of DNA-binding residues from sequence. Bioinformatics (ISMB Proceedings) 23, i347-353.
 * Y Ofran & B Rost (2007) Protein-protein interaction hotspots carved into sequences. PLoS Computational Biology 3, e119.
 * Y Bromberg & B Rost (2007) SNAP: predict effect of non-synonymous polymorphisms on function. Nucleic Acids Res 35, 3823-3835.
 * D Przybylski & B Rost (2007) Consensus sequences improve PSI-BLAST through mimicking profile-profile alignments. Nucleic Acids Res 35, 2238-2246, doi:10.1093/nar/gkm107.
 * Y Ofran & B Rost (2007) ISIS: Interaction Sites Identified from Sequence. Bioinformatics (ECCB’2006), 23, e13-e16.


 * A Schlessinger, Y Ofran, G Yachdav & B Rost (2006) Epitome: Database of structure-inferred antigenic epitopes. Nucleic Acids Res 34, D777-D780.
 * J Liu, J Gough & B Rost (2006) Distinguishing protein-coding from non-coding RNA through support vector machines. PLoS Genetics 2 (4):e29, DOI: 10.1371/journal.pgen.0020029.
 * S Mika & B Rost (2006) Protein–protein interactions more conserved within species than across species. PLoS Comp Biol 2, e79.
 * Y Ofran, G Yachdav, E Mozes, T Soong & B Rost (2006) Create and assess protein networks through molecular characteristics of individual proteins. Bioinformatics (ISMB Proceedings), 22: e402-e407.


 * M Punta & B Rost (2005) PROFcon: novel prediction of long-range contacts. Bioinformatics 21, 2960-2968.
 * A Schlessinger & B Rost (2005) Protein flexibility and rigidity predicted from sequence. Proteins 61, 115-126.
 * R Nair & B Rost (2005) Mimicking cellular sorting improves prediction of subcellular localization. J Mol Biol 348, 85-100.
 * M Punta & B Rost (2005) Protein folding rates estimated from contact predictions. J Mol Biol 348, 507-512.


 * B Rost, G Yachdav & J Liu (2004) The PredictProtein server. Nucl Acids Res, 32, W321-W326.
 * H Bigelow, D Petrey, J Liu, D Przybylski & B Rost (2004) Predicting transmembrane beta-barrels in proteomes. Nucl Acids Res 32, 2566-2577.


 * Y Ofran & B Rost (2003) Analysing six types of protein-protein interfaces. J Mol Biol 325, 377-387.


 * B Rost (2002) Did evolution leap to create the protein universe? Curr Opin Struct Biol 12, 409-416.
 * B Rost (2002) Enzyme function less conserved than anticipated. J Mol Biol 318, 595-608.


 * M Cokol, R Nair & B Rost (2000) Finding nuclear localization signals. EMBO Reports 1, 411-415.


 * B Rost (1999) Twilight zone of protein sequence alignments. Protein Engineering 12, 85-94.


 * B Rost (1998) Marrying structure and genomics. Structure 6, 259-263.
 * MA Andrade, SI O'Donoghue & B Rost (1998) Adaptation of protein surfaces to subcellular location. J Mol Biol 276, 517-525.


 * B Rost, R Schneider and C Sander (1997) Protein fold recognition by prediction-based threading. J Mol Biol 270, 471-480.
 * B Rost (1997) Protein structures sustain evolutionary drift. Folding & Design 2, S19-S24.


 * B Rost, R Casadio & P Fariselli (1996) Topology prediction for helical transmembrane proteins at 86% accuracy. Protein Science 5, 1704-1718.
 * B Rost (1996) PHD: predicting one-dimensional protein structure by profile-based neural networks. Methods in Enzymology 266, 525-539.


 * B Rost, R Casadio, P Fariselli & C Sander (1995) Prediction of helical transmembrane segments at 95% accuracy. Protein Science 4, 521-533.


 * B Rost, C Sander & R Schneider (1994) PHD - an automatic server for protein secondary structure prediction. CABIOS 10, 53-60.
 * B Rost & C Sander (1994) Conservation and prediction of solvent accessibility in protein families. Proteins 20, 216-226.
 * B Rost & C Sander (1994) Combining evolutionary information and neural networks to predict protein secondary structure. Proteins 19, 55-72.


 * B Rost & C Sander (1993) Prediction of protein secondary structure at better than 70% accuracy. J Mol Biol 232, 584-599.
 * B Rost & C Sander (1993) Improved prediction of protein secondary structure by use of sequence profiles and neural networks. PNAS 90, 7558-7562.
 * T Meitinger, A Meindl, P Bork, B Rost, C Sander, M Haasemann & J Murken (1993) Molecular modelling of the Norrie disease protein predicts a cystine knot growth factor tertiary structure. Nature Genetics 5, 376-380.


 * B Rost & Sander (1992) Jury returns on structure prediction. Nature 360, 540.


 * B Rost (1991) Sensor Networks for Verifying Disarmament of Aircraft. Bochum: UVB Universitätsverlag Brockmeyer, Book.