User:MarcoVergara/Rho kinase inhibitor

Molecular Mechanism: Rho kinase inhibitors act on Rho kinase by altering the conformation of the protein, disrupting translocation to the plasma membrane, preventing ATP-dependent phosphorylation, and blocking RhoA binding to ROCK. Some studies suggest that Rho kinase inhibitors also play a role in anti-angiogenesis by blocking ERK and Akt signaling pathways. Rho kinase inhibitor also functions by blocking rho-mediated dephosphorylation of MLC20.