User:MarinAlejadroMedina/ECOP

ECOP is a a novel protein that regulates NF-kappaB transcriptional activity and connected apoptotic response in IkappaBalpha-dependent manner.

Ectopic expression of ECOP increases NF-kappaB transcriptional activity by promoting nuclear translocation and DNA binding of NF-kappaB, and ECOP-induced NF-kappaB activation confers cellular resistance to apoptotic challenge. In ECOP knockdown cells, NF-kappaB transcriptional activity is suppressed due to delayed IkappaBalpha degradation, which results in a delayed nuclear translocation as well as decreased DNA binding of NF-kappaB. Suppression of NF-kappaB activation by ECOP knockdown increases cellular susceptibility to apoptosis.