User:MarinAlejadroMedina/Glycoprotein 100

= Glycoprotein 100 = Glycoprotein 100 (GP100) is a 661 amino acid long protein that contains differentiation antigens. GP100 is a membrane bound protein that is expressed in melanocytes and pigmented cells in the retina, and in most malignant melanomas. It has widely studied to be used as a target for melanoma immunotherapy. GP100 works in functions melanogensis, melanosome biogenesis, and melanin polymerization (Eisenberg)

There are different sequences of the GP100 peptide that could be used for immunization against tumors. According to a case study, modifications of GP100 such as GP100-209 and GP100-208 have shown a greater number of antigen specific CTL's (cytotoxic T lymphocytes) which can target and kill cancer cells (Eisenberg).