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CXorf67
Currently, there is not much known about the human CXorf67 gene or protein product. Aliases include MGC47837 and LOC340602 but the gene will be referred to as CXorf67 going forward. The gene’s Accession number is NM_203407 and the protein Accession number is NM_9819521. Its name is descriptive of the gene’s location in the human genome- Chromosome X open reading frame 67. The mRNA is 1939 base pairs in length and codes for a protein product of 503 amino acids1. The function of the protein is unknown. This gene is located on the short arm of the X chromosome at Xp11.22.

Literature
The CXorf67 gene was identified along with MBTD1 (malignant brain tumor domain-containing-1) as being involved with novel reciprocal translocation related to low-grade endometrial stromal sarcoma2. The gene was one of many suspected of having an association with increased risk of prostate cancer due to single nucleotide polymorphisms in the genes. CXorf67 was not analyzed in depth as was done for other genes believed to have a greater association to prostate cancer3. In both studies, no further investigation was performed on this gene and its possible implications as of late 2014.

Expression
Expression of this gene is generally low with protein localization predicted to be in the nucleus. The in vivo function and phenotype remain unknown. The 5’ untranslated region (UTR) in approximately 107 bp and the 3’ UTR about 314 bp in length4. Several transcription factors for CXorf67 are known and assays are available for many of them, GCNF, NF-YC, FOXL1 and Gfi-1 are just a few of the regulatory transcription factors mentioned for the gene. There are PCR assays and antibodies available for the gene5.

Paralogs and Orthologs
There are no paralogs or alternative splice forms for human CXorf67. This gene is entirely limited to mammals but is not present in all mammals such as the platypus, elephant, shrew, armadillo and others, see Figure 1. While the gene is present in many Laurasiatheria, it is not present in all organisms in the clade, and it is a similar case with rodents, as it is not present in mice or rats. It is odd that the gene does not exist in all members of these clades. Since the gene is present in many Laurasiatheria, we might imply that the gene aroseabout 94.2 million years ago4, or at least that it was present around the time when Laurasiatheria came about.