User:Mauzel/sandbox

S-phase kinase-associated protein 2 B is an F-box protein in the Skp, Cullin, F-box containing complex. SKP2B binds with other proteins in the cell, allowing the rest of the SCF-complex to ubiquitin the target. It is a splice variant of SKP2.

Oncogene
Although a SKP2-specific and a SKP2B-specific antibody have since been developed, previous antibodies bound to all isoforms of SKP2. Therefore, previous studies noted elevated SKP2 levels, but did not differentiate between SKP2A and SKP2B.

Interactions
This is an example:

SKP2 has been shown to interact with:
 * CCNA2,
 * CDK2,