User:Maxim Masiutin/sandbox/CYP4F2/research

Research
The molecular mediators, inducers, and inhibitors that regulate CYP4F2 expression have mostly been elucidated in in vitro systems:
 * There have been findings that retinoic acid (a metabolite of vitamin A1) and saturated fatty acids, such as lauric acid and stearic acid, induce CYP4F2. Besides that, there were findings that lovastatin induce CYP4F2.
 * There also have been findings that CYP4F2 is inhibited by peroxisomal proliferators, such as clofibrate, pirinixic acid, nafenopin and tibric acid; the anti-fungal drug ketoconazole, and sesamin - a molecule found in sesame oil and sesame seeds, also inhibit CYP4F2. Another study has shown that quercetin, tranylcypromine, and disulfiram also inhibit CYP4F2.
 * A study has found that the following substances do not inhibit CYP4F2: brincidofovir and azoles (except ketoconazole), namely posaconazole, fluconazole, and voriconazole.

With the exception of ketoconazole and sesamin, these findings have not been confirmed in clinical studies. The inhibitory effect of ketoconazole has been confirmed by a study of 21 participants with different CYP4F2*3 variants enrolled (8 for *1/*1, 7 for *1/*3, and 6 for *3/*3). The inhibitory effect of sesamin has been confirmed by a randomized, controlled crossover trial, where 33 overweight men and women consumed 25 grams per day of sesame (approximately 50 mg/d of sesame lignan) for 5 weeks, resulting in a 28% decrease in plasma and a 32% decrease in urinary 20-HETE, while urinary sodium, potassium, and blood pressure were not affected.