User:Mb17m/sandbox

[Created a new section under DNA repair and Cancer in DNA repair wikipedia page]

Impact of tumor mutational load on immune response in cancer Tumor specific mutations that range from 0.001 per megabase to more than 400 per megabase serve as peptide epitopes that are normally not present in the human genome. The fact that number of CD8+ T cells is more in tumors with high mutational load emphasizes the fact that these peptide epitopes, also known as the neoantigens serve to strengthen the T cell response in neoplasm. It is reported that some tumor suppressors that are involved in DNA repair when inactivated can lead to immune response. When the mismatch repair system is inactivated, accumulation of single nucleotide variants occurs. This generates the peptide epitopes that are considerably different from self-antigens and hence there is significant enhancement of Immune response[3]. When the mutations are not repaired oncogenic outgrowth can take place simultaneously with the activation of immune response. So, neoantigen specific T cell reactivity can be wonderful targets for immunotherapeutic interventions in cancer.