User:Mdchordia/Allosteric enhancers

Allosteric enhancers is term associated with positive allosteric modulator in pharmacology, biochemistry and medicinal chemistry. The allosteric enhancers bind to macromolecules like receptor, or other protein like enzyme at site distinclty separate "allosteric site" from that of their primary ligand site called as active site or "orthosteric site". The binding of allosteric enhancer to the protein as is does not have any effect on the function, however, in the presence of primary ligand or orthosteric ligand the function of the resulting ternery complex is enhanced. This superior protein function in the presence of allosteric enhancer is hypothesized to be caused by change is conformation of protein to the improved favourable binding to orthosteric ligand. In other words the binding affinity as well as the efficacy of orthosteric ligand to protein is altered to such an extent that the resulting function of protein is improved.