User:Mdfriedman/sandbox

According to O.M. Colvin in his study of the development of cyclophasphomide and its clinical applications, "Phosphoramide mustard, one of the principle toxic metabolites of cyclophosphamide, was synthesized and reported by Friedman and Seligman in 1954...It was postulated that the presence of the phosphate bond to the nitrogen atom could inactivate the nitrogen mustard moiety, but the phosphate bond would be cleaved in gastric cancers and other tumors which had a high phosphamidase content." O.M. Colvin (August 1999), "An Overview of Cyclophosphamide's Development and Clinical Applications," Current Pharmaceutical Design, 5(8):555-60.