User:Mecailam/Formylglycine-generating enzyme/Ntam97 Peer Review

Peer review
This is where you will complete your peer review exercise. Please use the following template to fill out your review.

General info

 * Whose work are you reviewing? Mecailam and Tdehart4
 * Link to draft you're reviewing: Formylglycine-generating enzyme

Lead
The lead section provides a concise introductory sentence explaining the general reaction formylglycine-generating enzyme (FGE) can catalyze and the two classes of this enzyme. The authors also did a nice job of providing the functional relevance of FGE by mentioning how the generated product fGly is essential to sulfatase activation. Overall, the information in the lead section was delivered in a concise and clear manner.

Content
The content section is overall good with up-to-date information but do miss a few key points.


 * A little bit of information is missing especially under the aerobic and anaerobic sections. The authors mentioned each enzyme class utilizes a distinct mechanism to convert cysteine to formylglycine. Therefore, if possible, an illustration for each mechanism will be greatly appreciated.
 * Moreover, FGE has been implicated in drug discovery and development. Thus, more information on this aspect will be helpful to the audience.

Tone and Balance
The overall tone is neural and strictly informative.

Sources and References
Mostly primary sources are utilized instead of secondary. This might be due to research on FGE is still ongoing and there is not enough information out there to generate a secondary resource article.

Organization
The overall article is well-organized and has good grammar and sentence structures.

Images and Media
The PyMol structure included for FGE was somewhat informative. As mentioned above, illustrations (if solved) for FGE reaction mechanism will convey more information.

Overall impressions
Overall, this article provides a good start to give the audience a general idea what this enzyme does and the associated disease when this enzyme is dysfunctional. The article does need to have more information on certain aspects associated with FGE (e.g. application in drug discovery and development). Moreover, references need to include more secondary sources if possible (instead of cherry-picking certain primary sources).