User:Medi98032

List of antibiotics From Wikipedia, the free encyclopedia Jump to navigationJump to search This list is incomplete; you can help by expanding it. The following is a list of antibiotics. The highest division between antibiotics is bactericidal and bacteriostatic. Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing. However, these classifications are based on laboratory behavior. In practice, both can effectively treat a bacterial infection.[1]

Contents 1	By coverage 1.1	MRSA 1.2	Pseudomonas aeruginosa 1.3	VRE 2	By class 3	Antibiotic candidates 4	See also 5	Notes 6	References By coverage The following are lists of antibiotics for specific microbial coverage.

MRSA Antibiotics that cover methicillin-resistant Staphylococcus aureus (MRSA):

Vancomycin[2] Teicoplanin[2] Linezolid[2] Daptomycin[2] Trimethoprim/sulfamethoxazole Doxycycline Ceftobiprole[3](5th generation) Ceftaroline (5th generation) Clindamycin Dalbavancin Fusidic acid Mupirocin (topical) Omadacycline Oritavancin Tedizolid Telavancin Tigecycline (also covers gram negatives) Pseudomonas aeruginosa Antibiotics that cover Pseudomonas aeruginosa:

Aminoglycosides Carbapenems Ceftazidime (3rd generation) Cefepime (4th generation) Ceftobiprole (5th generation) Ceftolozane/tazobactam Fluoroquinolones Piperacillin/tazobactam Ticarcillin/clavulanic acid VRE Antibiotics that cover vancomycin-resistant Enterococcus (VRE):

Linezolid Streptogramins Tigecycline Daptomycin By class See also pathogenic bacteria for a list of antibiotics sorted by target bacteria.

Antibiotics by class Generic name	Brand names	Common uses[4]	Possible side effects[4]	Mechanism of action Aminoglycosides Amikacin	Amikin	Infections caused by Gram-negative bacteria, such as Escherichia coli and Klebsiella particularly Pseudomonas aeruginosa. Effective against aerobic bacteria (not obligate/facultative anaerobes) and tularemia. All aminoglycosides are ineffective when taken orally as the stomach will digest the drug before it goes into the bloodstream. However aminoglycosides are effective in Intravenous, intramuscular and topical forms. Hearing loss Vertigo Kidney damage Binding to the bacterial 30S ribosomal subunit (some work by binding to the 50S subunit), inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA, leaving the bacterium unable to synthesize proteins vital to its growth. Gentamicin	Garamycin Kanamycin	Kantrex Neomycin	Neo-Fradin[5] Netilmicin	Netromycin Tobramycin	Nebcin Paromomycin	Humatin Streptomycin		Tuberculosis Spectinomycin(Bs)	Trobicin	Gonorrhea Ansamycins Geldanamycin		Experimental, as antitumor antibiotics		Block DNA transcription, either via inhibiting DNA-dependent RNA polymerase by binding to the β-subunit Herbimycin Rifaximin	Xifaxan	Traveler's diarrhea caused by E. coli Carbacephem Loracarbef	Lorabid	Discontinued		Prevents bacterial cell division by inhibiting cell wall synthesis. Carbapenems Ertapenem	Invanz	Bactericidal for both Gram-positive and Gram-negative organisms and therefore useful for empiric broad-spectrum antibacterial coverage. (Notes: MRSA resistance to this class. All are active against Pseudomonas aeruginosa except ertapenem.) Gastrointestinal upset and diarrhea Nausea Seizures Headache Rash and allergic reactions Inhibition of cell wall synthesis Doripenem	Doribax Imipenem/Cilastatin	Primaxin Meropenem	Merrem Cephalosporins (First generation) Cefadroxil	Duricef	Good coverage against Gram-positive infections. Gastrointestinal upset and diarrhea Nausea (if alcohol taken concurrently) Allergic reactions Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cefazolin	Ancef, Kefzol Cephradine Cephapirin Cephalothin Cefalexin	Keflex Cephalosporins (Second generation) Cefaclor	Distaclor, Ceclor, Raniclor	Less Gram-positive cover, improved Gram-negative cover. Gastrointestinal upset and diarrhea Nausea (if alcohol taken concurrently) - if contains methylthiotetrazole side group Hypoprothrombinemia - if contains methylthiotetrazole side group Allergic reactions Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cefoxitin Cefotetan	Ceftan Cefamandole Cefmetazole Cefonicid Loracarbef Cefprozil	Cefzil Cefuroxime	Ceftin, Zinacef (UK) Cephalosporins (Third generation) Cefixime (antagonistic with Chloramphenicol)[6]	Cefspan (Fujisawa), Suprax	Improved coverage of Gram-negative organisms, except Pseudomonas. Reduced Gram-positive cover. But still not cover Mycoplasma and Chlamydia Gastrointestinal upset and diarrhea Nausea (if alcohol taken concurrently) Allergic reactions Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cefdinir	Omnicef, Cefdiel Cefditoren	Spectracef, Meiact Cefoperazone [Unlike most third-generation agents, cefoperazone is active against Pseudomonas aeruginosa], combination Cefoperazone with Sulbactam makes more effective antibiotic, because Sulbactam avoid degeneration of Cefoperazone	Cefobid (discontinued) Cefotaxime	Claforan Cefpodoxime	Vantin, Banadoz Ceftazidime (Unlike most third-generation agents, ceftazidime is active against Pseudomonas aeruginosa, but less active against Staphylococci and Streptococci compare to other 3rd generation of cephalosporins)	Fortaz, Ceptaz Ceftibuten	Cedax Ceftizoxime Moxalactam Ceftriaxone (IV and IM, not orally, effective also for syphilis and uncomplicated gonorrhea)	Rocephin Cephalosporins (Fourth generation) Cefepime	Maxipime Covers pseudomonal infections.

Gastrointestinal upset and diarrhea Nausea (if alcohol taken concurrently) Allergic reactions Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Cephalosporins (Fifth generation) Ceftaroline fosamil	Teflaro	Used to treat MRSA Gastrointestinal upset and diarrhea Allergic reaction Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Ceftobiprole	Zeftera	Used to treat MRSA (methicillin-resistant Staphylococcus aureus), penicillin-resistant Streptococcus pneumoniae, Pseudomonas aeruginosa, and enterococci Gastrointestinal upset and diarrhea Nausea (if alcohol taken concurrently) Allergic reactions Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Glycopeptides Teicoplanin	Targocid (UK)	Active against aerobic and anaerobic Gram-positive bacteria including MRSA; Vancomycin is used orally for the treatment of C. difficile colitis		Inhibits peptidoglycan synthesis. Vancomycin	Vancocin Telavancin	Vibativ Dalbavancin	Dalvance Oritavancin	Orbactiv Lincosamides(Bs) Clindamycin	Cleocin	Serious staph-, pneumo-, and streptococcal infections in penicillin-allergic patients, also anaerobic infections; clindamycin topically for acne	Possible C. difficile-related pseudomembranous enterocolitis	Binds to 50S subunit of bacterial ribosomal RNA thereby inhibiting protein synthesis. Lincomycin	Lincocin Lipopeptide Daptomycin	Cubicin	Gram-positive organisms, but is inhibited by pulmonary surfactant so less effective against pneumonias		Binds to the membrane and cause rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis. Macrolides(Bs) Azithromycin	Zithromax, Sumamed, Xithrone	Streptococcal infections, syphilis, upper respiratory tract infections, lower respiratory tract infections, mycoplasmal infections, Lyme disease Nausea, vomiting, and diarrhea (especially at higher doses) Prolonged cardiac QT interval (especially erythromycin) Hearing loss (especially at higher doses) Jaundice Inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. Clarithromycin	Biaxin Erythromycin	Erythocin, Erythroped Roxithromycin Telithromycin	Ketek	Pneumonia	Visual Disturbance, Liver Toxicity.[7] Spiramycin	Rovamycine	Mouth infections Fidaxomicin	Dificid	Treatment of Clostridioides (formerly Clostridium) difficile infection.[8] May be more narrow-spectrum than vancomycin, resulting in less bowel microbiota alteration.[9]	Nausea (11%), vomiting, and abdominal pain.[10]	Bactericidal in susceptible organisms such as C. difficile by inhibiting RNA polymerase, thereby inhibiting protein synthesis.[10] Monobactams Aztreonam	Azactam	Gram-negative bacteria		Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Nitrofurans Furazolidone	Furoxone	Bacterial or protozoal diarrhea or enteritis Nitrofurantoin(Bs)	Macrodantin, Macrobid	Urinary tract infections Oxazolidinones(Bs) Linezolid	Zyvox	VRSA Thrombocytopenia Peripheral neuropathy Serotonin Syndrome Protein synthesis inhibitor; prevents the initiation step Posizolid	Phase II clinical trials Radezolid	Phase II clinical trials Torezolid	Sivextro Penicillins Amoxicillin	Novamox, Amoxil	Wide range of infections; penicillin used for streptococcal infections, syphilis, and Lyme disease Gastrointestinal upset and diarrhea Allergy with serious anaphylactic reactions Brain and kidney damage (rare) Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. Ampicillin	Principen (discontinued) Azlocillin Dicloxacillin	Dynapen (discontinued) Flucloxacillin	Floxapen (Sold to European generics Actavis Group) Mezlocillin	Mezlin (discontinued) Methicillin	Staphcillin (discontinued) Nafcillin	Unipen (discontinued) Oxacillin	Prostaphlin (discontinued) Penicillin G	Pentids (discontinued) Penicillin V	Veetids (Pen-Vee-K) (discontinued) Piperacillin	Pipracil (discontinued) Penicillin G	Pfizerpen Temocillin	Negaban (UK) (discontinued) Ticarcillin	Ticar (discontinued) Penicillin combinations Amoxicillin/clavulanate	Augmentin	Both Amoxicillin/clavulanate and Ampicillin/sulbactam are effective against non-recurrent acute otitis media.[11] Amoxicillin/clavulanate is one of the few oral antibiotics effective against skin and soft tissue infections. Can be given to children less than 40 kilograms in weight; for children heavier, the dosage is same as adults, twice daily.[12]		The second component reduces the effectiveness of some forms of bacterial resistance to the first component Ampicillin/sulbactam	Unasyn Piperacillin/tazobactam	Zosyn Ticarcillin/clavulanate	Timentin Polypeptides Bacitracin		Eye, ear or bladder infections; usually applied directly to the eye or inhaled into the lungs; rarely given by injection, although the use of intravenous colistin is experiencing a resurgence due to the emergence of multi drug resistant organisms. Kidney and nerve damage (when given by injection)	Inhibits isoprenyl pyrophosphate, a molecule that carries the building blocks of the peptidoglycan bacterial cell wall outside of the inner membrane[13] Colistin	Coly-Mycin-S	Interact with the Gram-negative bacterial outer membrane and cytoplasmic membrane, displacing bacterial counterions, which destabilizes the outer membrane. Act like a detergent against the cytoplasmic membrane, which alters its permeability. Polymyxin B and E are bactericidal even in an isosmotic solution. Polymyxin B	Quinolones/Fluoroquinolones Ciprofloxacin	Cipro, Ciproxin, Ciprobay	Urinary tract infections, bacterial prostatitis, community-acquired pneumonia, bacterial diarrhea, mycoplasmal infections, gonorrhea	Nausea (rare), irreversible damage to central nervous system (uncommon), tendinosis (rare)	Inhibits the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription. Enoxacin	Penetrex Gatifloxacin	Tequin Gemifloxacin	Factive[14] Levofloxacin	Levaquin Lomefloxacin	Maxaquin Moxifloxacin	Avelox Nadifloxacin Nalidixic acid	NegGram Norfloxacin	Noroxin Ofloxacin	Floxin (discontinued), Ocuflox Trovafloxacin	Trovan	Withdrawn Grepafloxacin	Raxar	Withdrawn Sparfloxacin	Zagam	Withdrawn Temafloxacin	Omniflox	Withdrawn Sulfonamides(Bs) Mafenide	Sulfamylon	Urinary tract infections (except sulfacetamide, used for eye infections, and mafenide and silver sulfadiazine, used topically for burns) Nausea, vomiting, and diarrhea Allergy (including skin rashes) Crystals in urine Kidney failure Decrease in white blood cell count Sensitivity to sunlight Folate synthesis inhibition. They are competitive inhibitors of the enzyme dihydropteroate synthetase, DHPS. DHPS catalyses the conversion of PABA (para-aminobenzoate) to dihydropteroate, a key step in folate synthesis. Folate is necessary for the cell to synthesize nucleic acids (nucleic acids are essential building blocks of DNA and RNA), and in its absence cells cannot divide. Sulfacetamide	Sulamyd, Bleph-10 Sulfadiazine	Micro-Sulfon Silver sulfadiazine	Silvadene Sulfadimethoxine	Di-Methox, Albon Sulfamethizole	Thiosulfil Forte Sulfamethoxazole	Gantanol Sulfanilimide (archaic) Sulfasalazine	Azulfidine Sulfisoxazole	Gantrisin Trimethoprim-Sulfamethoxazole (Co-trimoxazole) (TMP-SMX)	Bactrim, Septra Sulfonamidochrysoidine (archaic)	Prontosil Tetracyclines(Bs) Demeclocycline	Declomycin	Syphilis, chlamydial infections, Lyme disease, mycoplasmal infections, acne rickettsial infections, malaria[note 1] Gastrointestinal upset Sensitivity to sunlight Potential toxicity to mother and fetus during pregnancy Enamel hypoplasia (staining of teeth; potentially permanent) Transient depression of bone growth Inhibits the binding of aminoacyl-tRNA to the mRNA-ribosome complex. They do so mainly by binding to the 30S ribosomal subunit in the mRNA translation complex. But Tetracycline cannot be taken together with all dairy products, aluminium, iron and zinc minerals. Doxycycline	Vibramycin Metacycline Minocycline	Minocin Oxytetracycline	Terramycin Tetracycline	Sumycin, Achromycin V, Steclin Drugs against mycobacteria Clofazimine	Lamprene	Antileprotic Dapsone	Avlosulfon	Antileprotic Capreomycin	Capastat	Antituberculosis Cycloserine	Seromycin	Antituberculosis, urinary tract infections Ethambutol(Bs)	Myambutol	Antituberculosis Ethionamide	Trecator	Antituberculosis		Inhibits peptide synthesis Isoniazid	I.N.H.	Antituberculosis Pyrazinamide	Aldinamide	Antituberculosis Rifampicin (Rifampin in US)	Rifadin, Rimactane	mostly Gram-positive and mycobacteria	Reddish-orange sweat, tears, and urine	Binds to the β subunit of RNA polymerase to inhibit transcription Rifabutin	Mycobutin	Mycobacterium avium complex	Rash, discolored urine, GI symptoms Rifapentine	Priftin	Antituberculosis Streptomycin		Antituberculosis	Neurotoxicity, ototoxicity	As other aminoglycosides Others Arsphenamine	Salvarsan	Spirochaetal infections (obsolete) Chloramphenicol(Bs)	Chloromycetin	Meningitis, MRSA, topical use, or for low-cost internal treatment. Historic: typhus, cholera. Gram-negative, Gram-positive, anaerobes	Rarely: aplastic anemia. Inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome Fosfomycin	Monurol, Monuril	Acute cystitis in women	This antibiotic is not recommended for children and 75 and up of age	Inactivates enolpyruvyl transferase, thereby blocking cell wall synthesis Fusidic acid	Fucidin Metronidazole	Flagyl	Infections caused by anaerobic bacteria; also amoebiasis, trichomoniasis, giardiasis	Discolored urine, headache, metallic taste, nausea; alcohol is contraindicated	Produces toxic free radicals that disrupt DNA and proteins. This non-specific mechanism is responsible for its activity against a variety of bacteria, amoebae, and protozoa. Mupirocin	Bactroban	Ointment for impetigo, cream for infected cuts		Inhibits isoleucine t-RNA synthetase (IleRS) causing inhibition of protein synthesis Platensimycin Quinupristin/Dalfopristin	Synercid Thiamphenicol		Gram-negative, Gram-positive, anaerobes. Widely used in veterinary medicine. Rash. Lacks known anemic side-effects. A chloramphenicol analog. May inhibit bacterial protein synthesis by binding to the 50S subunit of the ribosome Tigecycline(Bs)	Tigacyl	Slowly Intravenous. Indicated for complicated skin/skin structure infections, soft tissue infections and complicated intra-abdominal infections. Effective for gram-positive, gram-negative, anaerobic, and against multi-antibiotic resistant bacteria (such as Staphylococcus aureus [MRSA] and Acinetobacter baumannii), but not effective for Pseudomonas spp. and Proteus spp. Teeth discoloration and same side effects as tetracycline. Not to be given for children and pregnant or lactate women. Relatively safe and no need dose adjusted when be given for mild to moderate liver function or renal patients	Similar structure with tetracycline, but 5 times stronger, big volume distribution and long half-time in the body Tinidazole	Tindamax Fasigyn	Protozoal infections	Upset stomach, bitter taste, and itchiness Trimethoprim(Bs)	Proloprim, Trimpex	Urinary tract infections Generic Name	Brand Names	Common Uses[4]	Possible Side Effects[4]	Mechanism of action Note: (Bs): Bacteriostatic

Antibiotic candidates These are antibiotic candidates, and known antibiotics that are not yet mass-produced.

Antibiotic candidates Generic name	Origin	Susceptible phyla	Stage of development	Mechanism of action Unclassified Teixobactin	Eleftheria terrae	Gram-positive, including antibiotic resistant S. aureus and M. tuberculosis	No human trials scheduled	Binds fatty acid precursors to cell wall Malacidins	Uncultured Bacterium	Gram-positive, including antibiotic resistant S. aureus	No human trials scheduled	Binds fatty acid precursors to cell wall Halicin	Anti-diabetic drug	Clostridiodes difficile, Acinetobacter baumannii, and Mycobacterium tuberculosis	No human trials scheduled	Disrupts electrochemical gradient See also Timeline of antibiotics, listed by year of introduction Pathogenic bacteria Notes Note: Malaria is caused by a protist and not a bacterium. References Pelczar, M. J.; Chan, E. C. S. and Krieg, N. R. (1999) "Host-Parasite Interaction; Nonspecific Host Resistance", In: Microbiology Concepts and Applications, 6th ed., McGraw-Hill Inc., New York pp. 478-479. 青木, 眞 (2015). レジデントのための感染症診療マニュアル. Japan: 医学書院. ISBN 978-4260020275. Zhanel GG, Lam A, Schweizer F, Thomson K, Walkty A, Rubinstein E, Gin AS, Hoban DJ, Noreddin AM, Karlowsky JA (2008). "Ceftobiprole: a review of a broad-spectrum and anti-MRSA cephalosporin". American Journal of Clinical Dermatology. 9 (4): 245–54. doi:10.2165/00128071-200809040-00004. PMID 18572975. For common Uses and possible side effects reference is: Robert Berkow (ed.) The Merck Manual of Medical Information - Home Edition. Pocket (September 1999), ISBN 0-671-02727-1. "Neomycin Drug Information". uptodate. Retrieved November 2, 2012.(subscription required) Berger, Dr. Stephen (2014-04-03). GIDEON Guide to Antimicrobial Agents (2014 ed.). GIDEON Informatics Inc. p. 221. ISBN 9781617558399. Retrieved 4 February 2015. Splete, Heidi; Kerri Wachter (March 2006). "Liver toxicity reported with Ketek". Internal Medicine News. McDonald LC, Gerding DN, Johnson S, Bakken JS, Carroll KC, Coffin SE, Dubberke ER, Garey KW, Gould CV, Kelly C, Loo V, Shaklee Sammons J, Sandora TJ, Wilcox MH (March 2018). "Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)". Clinical Infectious Diseases. 66 (7): e1–e48. doi:10.1093/cid/cix1085. PMC 6018983. PMID 29462280. Tannock GW, Munro K, Taylor C, Lawley B, Young W, Byrne B, Emery J, Louie T (November 2010). "A new macrocyclic antibiotic, fidaxomicin (OPT-80), causes less alteration to the bowel microbiota of Clostridium difficile-infected patients than does vancomycin". Microbiology. 156 (Pt 11): 3354–9. doi:10.1099/mic.0.042010-0. PMID 20724385. Dificid (fidaxomicin) [prescribing information] Whitehouse Station, NJ: Merck; December 2015. Casellas JM, Israele V, Marín M, Ishida MT, Heguilen R, Soutric J, Arenoso H, Sibbald A, Stamboulian D (September 2005). "Amoxicillin-sulbactam versus amoxicillin-clavulanic acid for the treatment of non-recurrent-acute otitis media in Argentinean children". International Journal of Pediatric Otorhinolaryngology. 69 (9): 1225–33. doi:10.1016/j.ijporl.2005.03.016. PMID 16061111. "APO-Amoxycillin and Clavulanic Acid 500mg/125 mg Tablets" (PDF). Retrieved November 27, 2014. Mechanism of Action of Bacitracin: Complexation with Metal Ion and C55-Isoprenyl Pyrophosphate K. John Stone and Jack L. Strominger "List of Antibiotics". Retrieved February 7, 2014. vte Antibiotics − social and layperson issues Concepts AntibacterialFungicideAntiviral drugAntiparasiticAntimicrobial Social issues Timeline of antibioticsAntibiotic resistanceAntibiotic misuseAntibiotic use in livestock Pharmacology Antimicrobial pharmacodynamicsList of antibioticsProduction of antibiotics Categories: Antibiotics Navigation menu Not logged inTalkContributionsCreate accountLog in ArticleTalk ReadEditView historySearch Search Wikipedia Main page Contents Current events Random article About Wikipedia Contact us Donate Contribute Help Community portal Recent changes Upload file Tools What links here Related changes Special pages Permanent link Page information Wikidata item Cite this page

Languages বাংলা Български Català Español עברית Edit links Print/export Download as PDF Printable version This page was last edited on 1 June 2020, at 22:39 (UTC). Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia