User:Meodipt/2009 talk archive

File:Hexobarbital.png
Hi Meodipt, I just wanted to let you know that I have deleted File:Hexobarbital.png in order to allow a similar, but higher resolution, version on Commons to be displayed instead. If you have any objections, please let me know. -- Ed (Edgar181) 18:49, 13 January 2009 (UTC)

brasofensine
Hello, I see you put it as class A, but I couldn't find it in the list, unless it's "3-(3,4-Dichlorophenyl)-8-Methyl-8-Aza-Bicyclo(3.2.1) Octane-2-Carbaldehyde-0-Methyloxine" - could you clarify? thanks, (please reply on the brasofensine talk page, thanks)--193.128.72.68 (talk) 17:04, 15 January 2009 (UTC)

Thanks
Thanks for your work on synthetic cannabinoid articles.  Tu rk ey ph an t 00:11, 24 January 2009 (UTC)

A centralised discussion which may interest you
Hi. You may be interested in a centralised discussion on the subject of "lists of unusual things" to be found here. SP-KP (talk) 17:36, 27 January 2009 (UTC)

Re: EA-3167 Article
Reading the National Academy ref, it becomes apparent, that the ref contains many factual incoherencies and contradictions, leaving the impression that the material has been heavily redacted/censored for release. Example: "succinate" mentioned as an antidote (what succinate?), and many more. It leaves the question, if the ref is suitable as a sole reference for this kind of articles and otherwise factually accurate. I doubt it. Seemingly they just skipped over the "blacked out parts" and eventually applied edits to obfuscate the material. 70.137.130.4 (talk) 23:52, 8 February 2009 (UTC)

We agree. Just wanted to tell you my impression of a fragmentary and at times incoherent source, which may be obfuscated, or the result of skipping over black bars. The (censored mg of censored) succinate are a good example. Excellent work you are doing! 70.137.130.4 (talk) 06:32, 10 February 2009 (UTC)

Images
A number of images you upload are in png format but are better suited for SVG format. Please consider using inkscape or BKchem (for chemical compounds) to convert your images to svg format(which allows the image to be enlarged without quality loss). To see a simple difference look at your png version PNG and the SVG counterpart SVG or [PNG] and [SVG]. Please check the program you are using to see if images can be saved as svgs. If you need help, let me know. Smallman12q (talk) 15:17, 15 March 2009 (UTC)

Serotonin Ligands
Hmm.. how could we reformulate it best? Well I'm planning to add all the articles for research chemicals like RU 24969 and WAY-100,135 and such, so yeah we could just do selective ligands. We could also put the popular recreational ones like regarding the 5-HT2A receptor, LSD, psilocybin/psilocin, DMT, mescaline, and 2C-B and such. —Preceding unsigned comment added by Rocknroll714 (talk • contribs) 18:35, 27 April 2009 (UTC)

Antidepressant Table
Hey dude I'm working on that. —Preceding unsigned comment added by Rocknroll714 (talk • contribs) 07:36, 28 April 2009 (UTC)

Alright no problem. I'll keep that in mind for the future. —Preceding unsigned comment added by Rocknroll714 (talk • contribs) 07:50, 28 April 2009 (UTC)

Response
Hello. Thank you for not reverting it. It is indeed a little less informative, but the old table was definitely not very useful. Mianserin was classified as an AA. Many of the TCAs are AAs as well. The AA component isn't even really the cause of the antidepressant effects however. It's more likely than it's the 5-HT2C blockade which is really helping. Regarding the TCAs, many of them we don't know their selectivity for the various transporters. Hence it's better to plop them all in one big group and have the individual pages list their properties. I plan to go through and edit them as much as I can in the future. I already took a shot at the TCA main thread as you might have seen. I plan to do some more work on the table in the future as well, but nothing radical. Just small changes like new category members and such. —Preceding unsigned comment added by Rocknroll714 (talk • contribs) 11:59, 28 April 2009 (UTC)

Hello
I'd just like to say thank you for going over my edits and putting in the drug boxes in my new articles and such. I appreciate it! Rocknroll714 (talk) 06:33, 30 April 2009 (UTC)

I definitely agree. I'm not the most chemistry savvy person around though. I might look into it in the future. Rocknroll714 (talk) 07:05, 30 April 2009 (UTC)

5-IAI
I'm thinking the lowered serotonin markers might simply be tolerance/downregulation as Nichols said it was "non-neurotoxic". What are your thoughts? Rocknroll714 (talk) 08:13, 30 April 2009 (UTC)

WP:PHARM:CAT
There is ongoing discussion and work to categorize pharmacology-related articles in an organized way. If available, perhaps you could join in the discussion at WP:PHARM:CAT? Regardless, thank you for your work on wikipedia. ---kilbad (talk) 13:36, 2 May 2009 (UTC)

Cardiac fibrosis
Nice work finding even more references to serotinergics on this. The article as it stands may be a more complete treatment of the various drug offenders than exists in the standard pharm literature. The old articles on 5-HIAA urine excretion in Matoke-eaters in West Africa are pre-1965 and not well-known. I'm looking for them. Somebody needs to get ALL this new mechanistic stuff and the various drug recall things together, plus the old green banana stuff, and write it all up for some journal as a review. Oh, and by the way, nice to make your acquaintence here on WP. It's sometimes not a friendly place for academic experts, but you seem to be doing well. S B Harris 02:06, 12 June 2009 (UTC)

Serotonergics
Thank you.

I don't think it would hurt to just leave it there. I mean I added this and it was fine:


 * Melatonin_receptor_1C

What do you think?


 * Hmm. I think if we just put in a disclaimer that it isn't functional in humans it'd be alright? Also, would you like to help with an adrenergics template and possibly do something like this by any chance? -> Clickie. I'm dying doing all this on my own lol.. Rocknroll714 (talk) 01:20, 15 June 2009 (UTC)


 * Thanks. No problem. Mmm k I think you're right it might be a bit much.. Also yeah, I've been looking all over for something like that but I can't find any info.. I'd love to see how DMT and such bind to say 5-HT4 and all those. The only one we've really determined so far is LSD as far as I can tell. Rocknroll714 (talk) 01:33, 15 June 2009 (UTC)

NowCommons: File:Ditran.png
File:Ditran.png is now available on Wikimedia Commons as Commons:File:Ditran.png. This is a repository of free media that can be used on all Wikimedia wikis. The image will be deleted from Wikipedia, but this doesn't mean it can't be used anymore. You can embed an image uploaded to Commons like you would an image uploaded to Wikipedia, in this case:. Note that this is an automated message to inform you about the move. This bot did not copy the image itself. --Erwin85Bot (talk) 11:37, 15 June 2009 (UTC)
 * File:Methoserpidine.png is now available as Commons:File:Methoserpidine.png. --Erwin85Bot (talk) 17:07, 8 August 2009 (UTC)
 * File:Pirlindole.png is now available as Commons:File:Pirlindole.png. --Erwin85Bot (talk) 15:39, 13 August 2009 (UTC)
 * File:6-OHDA.png is now available as Commons:File:6-OHDA.png. --Erwin85Bot (talk) 13:53, 26 September 2009 (UTC)
 * File:EA-3148 structure.png is now available as Commons:File:EA-3148 structure.png. --Erwin85Bot (talk) 17:48, 1 October 2009 (UTC)

GABAergics
Hey. How do you think I should merge these?:

Any suggestions? Rocknroll714 (talk) 19:35, 17 June 2009 (UTC)


 * Haha thanks! Yeah I'm not too sure how I'm gonna do the GABAergics template, but I'll figure it out. As for methaqualone and even the carbamates and such, I'm sure "putative" PAMs would suffice. Rocknroll714 (talk) 22:25, 17 June 2009 (UTC)

Bicuculine
I'm not so sure. Take a look at this:


 * http://www.jneurosci.org/cgi/content/full/17/2/625

"These observations indicate that the blocking drugs can produce allosteric changes in GABAA receptors, at least those containing this mutated 2 subunit. We conclude that the sites for binding steroids and barbiturates do not overlap with the GABA-binding site. Furthermore, neither gabazine nor bicuculline competes for binding at the steroid or barbiturate sites. The data are consistent with a model in which both gabazine and bicuculline act as allosteric inhibitors of channel opening for the GABAA receptor after binding to the GABA-binding site."

They seem to bind to the GABA recognition site, but I'm not exactly sure what the "allosteric" deal is.

-

Spot on. Check this out:


 * http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1572371

"Bicuculline is a GABAA receptor antagonist and competitively inhibits GABA induced currents (Curtis et al., 1970). Additionally, it displays properties of an allosteric modulator as shown by inhibition of pentobarbital induced currents (Ueno et al., 1997). All derivatives surprisingly lost their ability to bind to the site for GABA and some of these interestingly potentiated currents elicited by GABA. The most potent compounds were arylsulphonyl-tetrahydro-isoquinolines, and their structure was further optimized, leading finally to a molecule that allosterically stimulated the GABAA receptor and had only a very weak affinity for the benzodiazepine binding site. One of these compounds was named (+)-ROD188 ((1R, 2′R)-1-(2,3,4,5-Tetrahydro-5-oxo-2-furyl)-2-N-(p-toluene-sulphonyl)-1,2,3,4-tetrahydroisoquinoline; Figure 1) and analysed in more detail."

Refs
Sorry about that, I actually just discovered this yesterday:


 * http://toolserver.org/~diberri/cgi-bin/templatefiller/index.cgi

That thing is SO useful. I added the references to the tripelennamine page just now. Check the last one. Here's its dissociation constants:


 * Tripelennamine: SERT - 89.6; DAT - 214.

Before I was doing them all manually which was a major pain. I'll be adding them consistently from now on. Rocknroll714 (talk) 23:01, 20 June 2009 (UTC)


 * lol, i'll change it to "weak". Rocknroll714 (talk) 23:06, 20 June 2009 (UTC)

BD FAC
Dear Meodipt. I just happened to read the thoughtful comments you posted on LG's Talk page a few days ago. Although you may be critical of me personally, I wholeheartedly agree with what you wrote about the content of Benzodiazepine article. I would like to reiterate my position already voiced at the BD Talk and elsewhere.

I would gladly take the paragraph(s) you have written on any contentious issue as a starting point, or even in toto without changes. Your lead on resolving the dispute would be much appreciated, and I promise to follow your recommendations.

Unfortunately, LG imploded over relatively minor corrections, and at the point where FA promotion was within reach. It was as frustrating to me as to other people who worked hard to remake the unholy mess that was the original nomination into an excellent article. I am interested in moving the process forward.

Sincerely, The Sceptical Chymist (talk) 11:22, 9 July 2009 (UTC)

Recent contribs
Aff, for some reason I kept thinking 5-(2-aminopropyl)indole was indanylaminopropane haha. That's why I was removing it, thought it was a duplicate. Didn't realize the indane vs indole at the time. My bad, silly me.

Regarding rolicyclidine, I believe it has reduced DRI activity in comparison to phencyclidine, not negligible action. But then again I haven't personally taken an in-depth look at it and I could very well be wrong.

As for the rest of it, thanks for bringing it all to my attention. I wasn't aware of those D1 partial agonists not qualifying as stimulants. I just grouped them all together for consistency's sake at the time. I was aware of D2-like agonists being depressant though (I've tried one before, very sedating and relaxing, though it also made me vomit like I never have before heh). Feel free to tweak my changes any way you'd like. Also, to my understanding references aren't typically used in templates? It's not necessarily a rule of course by any means but I rarely if ever see citation notes in them. Nonetheless, I admit I have been semi-slacking off on my citations recently though.

Rocknroll714 (talk) 00:44, 11 August 2009 (UTC)

Thiomethisosildenafil for DYK?
Hi. I've nominated Thiomethisosildenafil, an article you worked on, for consideration to appear on the Main Page as part of Did you know. You can see the hook for the article here, where you can improve it if you see fit. PFHLai (talk) 05:01, 12 August 2009 (UTC) Thanks, PFHLai (talk) 05:01, 12 August 2009 (UTC)

Indolylaminopropane
Hmm.. they might be confused. How bout I leave it up to you? El3ctr0nika (talk) 21:52, 12 September 2009 (UTC)

I've never even heard of that compound b4. Only p- and m- isomers as far as im aware.--Nuklear (talk) 21:38, 14 September 2009 (UTC)

List of benzodiazepines
Hi Meodipt, I see that you did [http://en.wikipedia.org/w/index.php?title=List_of_benzodiazepines&diff=315687635&oldid=315353316 this edit. The problem is is that the section you put the dose in is "equivalent dose", so by adding in a therapeutic dose as you did would lead many readers to think that it is an "equivalent dose". I removed it because I thought that it was confusing to the reader.-- Literature geek |  T@1k?  02:26, 24 September 2009 (UTC)

None of the other drugs listed have a typical therapeutic dose listed (per Manual_of_Style_(medicine-related_articles)) for them either and the article is not about overdose so again is confusing. What are your thoughts? :)-- Literature geek |  T@1k?  02:34, 24 September 2009 (UTC)

Cholinergics
Thanks for the help :) el3ctr0nika (Talk | Contribs) 07:36, 3 December 2009 (UTC)

Safrazine
Doesn't it still actually contain MDA, it just has a little extra bulk on the side chain (e.g., methyl-propyl)? It would actually be BDB, correct? I'll remove the stuff from the page though, thanks for the clarification! el3ctr0nika (Talk | Contribs) 11:01, 5 December 2009 (UTC)


 * Gotcha. el3ctr0nika (Talk | Contribs) 11:08, 5 December 2009 (UTC)