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User:Skysmith/Missing_topics_about_Chemistry

#1
Pharmacological Profile of Selected Agents in the Dopamine, Norepinephrine and 5-HT Release and Uptake Inhibition Assays:

Source: Rothman RB, Baumann MH. (2006) Therapeutic Potential of Monoamine Transporter Substrates. Current Topics in Medicinal Chemistry. 6(17), 1845-1859. Pubmed Link.

#2
Pharmacological Profile of Selected Agents in the DA, NE and 5-HT Release and Uptake Inhibition Assays:

Source(s):


 * PDF


 * PDF

#3
Effect of Test Agents on Biogenic Amine Release or Uptake [EC50 (nM ± S.D.)]:

Source: Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, Glennon RA. (2003) In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J Pharmacol Exp Ther. 307(1), 138-145. Pubmed Link, PDF Link.

#4
In Vitro Potency as Releasers of Monoamine Neurotransmitters:

Source: Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL. (2005) Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs. J Pharmacol Exp Ther. 313(2), 848-854. 15677348 Pubmed Link, PDF Link.

#5
Comparison of the Ki (μM) Values of Five Psychostimulants to Inhibit Human and Mouse Monoamine Transporters:

Source: Han DD, Gu HH. (2006) Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol. 6(6). Pubmed Link, PDF Link.

#6
Antidepressants: Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for the Receptors of Human Brain Frontal Cortex or Caudate Nucleus:

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#7
Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for Antidepressants at Human Brain Receptors:

Source:


 * PDF

#8
Affinities (Ki (nM) ± S.E.M.) of Typical and Atypical Antidepressants for the Cloned Rat 5-HT2A and 5-HT2C Receptors (and SERT for comparison):

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#9
Antidepressants: Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) and Selectivity for the Human Serotonin, Norepinephrine and Dopamine Transporters:

The Related Compounds: Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for the Human Serotonin, Norepinephrine and Dopamine Transporters:

Source:


 * PDF

#10
Affinty of Antipsychotic Drugs for Human Neurotransmitter Receptors (Ki, nM):


 * Note: 5-HT1D values are for bovine tissue.

Source(s):


 * PDF



#11
Neuroleptics: Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for the Receptors of Human Brain Frontal Cortex or Caudate Nucleus:

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#12
Binding Data (Ki (nM)) for Typical and Atypical Antipsychotic Drugs as Used in This Study:

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#13
Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for Antipsychotic Drugs at Human Brain Receptors:

Source:


 * PDF

#14
Neuroleptics: Equilibrium Dissociation Constants (KD (nM) ± S.E.M.) for the Human Serotonin, Norepinephrine, and Dopamine Transporters:

Source:


 * PDF

#15
Inhibition of Opioid Binding and Neurotransmitter Uptake:

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#16
The Ki Values of Drugs for Sigma-1, Sigma-2 and NMDA (PCP site) Receptors in Rat Brain Membranes:

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#17
All values are for human receptors except for α2D-adrenergic which is for the rat receptor (due to this receptor not being present in humans and only in rodents). Also the ropinirole values for 5-HT3 and 5-HT4 are for house and guinea pig receptors, respectively.

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#18
Affinities of Tandospirone, Buspirone, Ipsapirone, and Gepirone for Neurotransmitter Receptor Binding Sites:

Source: Hamik A, Oksenberg D, Fischette C, Peroutka SJ. (1990) Analysis of Tandospirone (SM-3997) Interactions With Neurotransmitter Receptor Binding Sites.  Biol Psychiatry. 28(2), 99-109. Pubmed Link

#19
Ki Values of Test Drugs at 5-HT2 Receptors:

Values are mean ± SEM (n=3). Units are nanomolar (nM).

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#20
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#21
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#22
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