User:Mereno1/Coagulative necrosis

Coagulative necrosis is a type of accidental cell death typically caused by ischemia or infarction. In coagulative necrosis, the architectures of dead tissue are preserved for at least a couple of days. It is believed that the injury denatures structural proteins as well as lysosomal enzymes, thus blocking the proteolysis of the damaged cells. The lack of lysosomal enzymes allows it to maintain a "coagulated" morphology for some time. Like most types of necrosis, if enough viable cells are present around the affected area, regeneration will usually occur. Coagulative necrosis occurs in most bodily organs, excluding the brain.

Coagulative necrosis can also be induced by high local temperature; it is a desired effect of treatments such as high intensity focused ultrasound applied to cancerous cells.

Microscopically, coagulative necrosis causes cells to appear to have the same outline, but no nuclei.

Coagulative Necrosis in Treatments
Coagulative necrosis can be induced for treatments of cancers. For example, radiofrequency (RF) energy can be used in liver resection surgeries to produce coagulative necrosis, creating a coagulative necrosis zone. This coagulates the liver resection margins and is useful in liver resection surgeries for helping to stop bleeding within the resection margin, increasing the safety margin. To achieve coagulative necrosis in tumor tissue, it only takes around 20 minutes of application with the RF probe. Additionally, high-intensity focused ultrasound (HIFU) also induces coagulative necrosis in target tumors. Both of these treatments use coagulative necrosis in treatment of cancer.