User:Michjkelley/Chromatolysis

Chromatolysis: Wikipedia Article Proposal
Michele Kelley, Aeri Alexander, Robert Olp, Christian Molony

Definition
Chromatolysis is the disintegration of chromophil, a substance found in the body of a nerve cell, which can result from cell exhaustion or damage to peripheral processes. Axonal damage can lead to various physical or biochemical changes in the neuronal cell body. Cytoskeleton alterations are the main cellular reaction to chromatolysis. Based on their location within the brain, some neurons appear to be more susceptible to peripheral chromatolysis.

Types

 * 1) Central Chromatolysis
 * 2) Peripheral Chromatolysis

Causes

 * Axotomy (the cutting or severing of a neuron's axon)
 * Lithium Poisoning
 * Acrylamide Intoxication

Chemical Mechanisms

 * Nissl Bodies
 * Chromophil

Associated Diseases

 * Fetal Alcohol Syndrome
 * Alzheimer’s
 * ALS
 * Prick’s Disease
 * Corticobasal Degeneration