User:Microbio15/sandbox

 Morphology :

Outer membrane protein:

 Human Pathogenicity: 

How the disease is diagnosed:

Currently, in best practices, the disease is diagnosed by a microscopic agglutination test, MAT, but this test is unable to detect the disease during early stages. Combining diagnostic tests with a MAT, such as a PCR test, improves the diagnosis of the disease during its early stages. Recent studies are improving the PCR tests in hopes to increase the diagnostic accuracy by utilizing tests that target 16S ribosomal RNA and lipl32 genes.

Utilizing Koch's Postulates, the Loa22 gene has been classified as a virulence factor.

Sentence structure change:

The spirochete pathogen Leptospira interrogans is the main cause of human leptospirosis. In humans, disease caused by L. interrogans is classified as either icteric or anicteric.

The spirochete pathogen Leptospira interrogans is the main cause of human leptospirosis. In humans, symptoms caused by L. interrogans are biphasic, icteric or anicteric.

Papers to cite :

Verma, V.; Kala, D.; Gupta, S.; Kumar, H.; Kaushal, A.; Kuˇca, K.; Cruz-Martins, N.; Kumar, D. Leptospira interrogans Outer Membrane Protein-Based Nanohybrid Sensor for the Diagnosis of Leptospirosis. Sensors 2021, 21, 2552. https://doi.org/10.3390/ s21072552 Ristow, Paula et al. “The OmpA-like protein Loa22 is essential for leptospiral virulence.” PLoS pathogens vol. 3,7 (2007): e97. doi:10.1371/journal.ppat.0030097