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The mission of the Center for Reticular Chemistry (CRC) at the California NanoSystems Institute (CNSI) at UCLA is to provide national and international leadership in all aspects of reticular chemistry research and development, and to establish CNSI as an intellectual hub for researchers in the field. Reticular chemistry concerns the design and production of classes of compounds now known as metal-organic frameworks (MOFs),<ref name="K. Sanderson (2007). "Materials Chemistry: Space Invaders". Nature 448: 746. doi:10.1038/448746a. zeolitic imidazolate frameworks (ZIFs), and covalent organic frameworks (COFs) developed by Omar Yaghi.

Reticular chemistry involves linking of molecular building blocks of synthetic and biological origin into predetermined structure using strong bonds. This chemistry has led to the design and synthesis of new materials with enormous diversity. Researchers at the CRC are leading a revolution in the invention of new classes of porous crystalline materials, including MOFs. These materials have nanopores that can be functionalized by organic units and their metrics varied at will. MOFs have surface areas up to 6000 m2/g and are the least dense crystals known. To date over 3,000 new compositions of MOFs have been reported and studied for their applications in hydrogen storage, methane transport, carbon dioxide capture, polymerization catalysis, gas and liquid separations, magnetism, electronics and proton conduction. Interdisciplinary projects in progress at CNSI, UCLA are expected to advance this technology to other fields including engineering, mathematics, biology, physics and medicine.