User:Mim.cis/sandbox/Jamie Spangler

Jamie Spangler (born 1984) is an American bioengineer whose work is focused on the area of molecular immunoengineering. She is an assistant professor at Johns Hopkins University, jointly appointed in the departments of Biomedical and Chemical & Biomolecular Engineering. Her lab is based at the Johns Hopkins School of Medicine, within the Translational Tissue Engineering Center.

Biography
Spangler obtained a Bachelor of Science degree in Biomedical Engineering at Johns Hopkins University and went on to conduct her Ph.D. research in Biological Engineering in Professor K. Dane Wittrup’s group at MIT, studying antibody-mediated down-regulation of epidermal growth factor receptor as a new mechanism for cancer therapy. She is currently a postdoctoral fellow in Professor K. Christopher Garcia’s lab in the Molecular & Cellular Physiology and Structural Biology departments at Stanford University School of Medicine. Her work there focused on engineering cytokine systems to therapeutically bias immune homeostasis.

Spangler has been awarded a National Defense Science and Engineering Graduate Fellowship, a Repligen Koch Institute for Integrative Cancer Research Fellowship , and a Leukemia & Lymphoma Society postdoctoral fellowship for her research.

In 2017, Spangler was appointed as an assistant professor of Biomedical and Chemical & Biomolecular Engineering at Johns Hopkins. Her research group aims to redesign existing proteins and engineer new proteins to modulate the immune response for disease therapy. Synthesizing technologies from structural biophysics, molecular engineering, and translational immunology, her group seeks new insights into the molecular mechanisms underlying protein behavior in order to develop new technologies and platforms for targeted therapeutic discovery.