User:Miniroovigilante/NicotineAgonistsInfo

alpha-7 Nicotinic Acetylcholine receptor --


 * http://ajrcmb.atsjournals.org/cgi/content/full/41/1/93 - "Nicotine Activates and Up-Regulates Nicotinic Acetylcholine Receptors in Bronchial Epithelial Cells"   -- [ Genistein amplifies Nicotinic current ? ]

possesses pre & post-synaptic binding sites, with various [competitive, non-competitive, agonist-self-antagonist[ ?? ]], PAM/positive allosteric modulator, ect.....? ].   +  agonized by Nicotine, Acetylcholine, Choline [partial agonist], 5-hydroxyindole, Varenicline?**,   PAMs=  Type 1: Genistein, Type 2:

http://www.ncbi.nlm.nih.gov/pubmed/17016503?dopt=Citation

http://www.ncbi.nlm.nih.gov/pubmed/16427662

http://www.ncbi.nlm.nih.gov/pubmed/15561436

http://en.wikipedia.org/wiki/Linoleic_acid

Nicotinic Agonists:


 * Nicotine
 * Varenicline

Positive Allosteric Modulators:


 * Ivermectin
 * Genistein
 * Tropisetron

Unspecified Agonists/PAMs


 * Galantamine -  semi-selective PAM to alpha-7,  http://www.nature.com/npp/journal/v32/n1/full/1301087a.html
 * Anabaseine
 * Choline  ( selective-sorta   for alpha-7 )

--

Antagonists:


 * Memantine
 * Bupropion
 * Amantadine

Acetylcholinerase-whatever its called - Inherbitors :


 * Galantamine [ + PAM at a-7 receptors 0


 * Huperzine A [ also an -  NMDA  antagonist *** ]  ( check for more targets/affinities, Huperzine A is likely to have other unknown targets )


 * acetylcholinerase inhibitors, including Huperzine A, appear to have various NMDA antagonist activity,  - [ this is NOT the right study i was referencing too, but it applies anyway )   link to the article

NMDA / Nicotinic / Muscarinic  Antagonists:


 * Procyclidine

http://jpet.aspetjournals.org/content/313/2/930.full

galantamine + Varenecline + [  muscarinic Antagonist ? ]

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473179/