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FAM63B

Features

FAM63B is a protein coding gene of unknown function containing 621 amino acids. The gene is located on chromosome 15, on the plus strand of the short arm from 58,771,192 bp from pter to 58,861,900 bp from pter. FAM63B can be alternatively spliced to create 10 mRNA variants, and variant 1 is the longest of these. The protein encoded by FAM63B contains a domain of unknown function (DUF544) belonging to the Pfam superfamily. FAM63B protein also contains a bipartite tryptophan binding motif from Trp476 to Trp533.

Expression

FAM63B is expressed at a level 3.0 times higher than the average gene at release. FAM63B is expressed in over 70 tissue types throughout the body, including in the kidney, brain, eye, placenta, testis, breast, and muscle.

Function

FAM63B is a gene of unknown function. It has been associated with the recruitment of kinesin-1 via the kinesin light chain and the transport of viruses into the cell periphery. FAM63B may also be a biomarker for the detection and treatment of schizophrenia due to aberrant methylation of the gene. FAM63B has also been associated with other genes relevant to arthritis.

Orthologs

FAM63B has been found in all multicellular and unicellular eukaryotes, including plants but excluding protists and fungi. It has also been found in archaea but not bacteria. A list of 20 orthologs of FAM63B and its paralog, FAM63A, is found in Table 1.