User:Mjavorski/Spike-and-wave

Wikipedia Proposal: Spike-and-Wave

The following is a proposal for a project on spike-and-wave patterns done by Mike Javorski, Tyler Popp, and Blake Pierce. Each member will be assigned specific sections from the outline. We will meet once a week, after class to discuss and review our individual additions made to the wikipedia page.

General Definition and Introduction

 * What is spike-and-wave?
 * Pictures of normal EEG and of EEG during absence seizure
 * The pattern is generally seen in which diseases?
 * Who is generally affected and what does it mean/how is it abnormal?
 * Average pattern in normal human/animals and average of those affected?

Function and Mechanisms Involved in Spike-and-Wave

 * Anatomy and function of Cerebral Cortex (Avoli article)
 * initiates in the cortex
 * sharpness of spike may correspond to decrease in size of the epileptogenic zone (Jaseja article)
 * Anatomy and function of Thalamus (Avoli article)
 * still equal in importance
 * How they work together

Absence Seizures

 * Brief intro of seizures, what goes on in the brain
 * Absence seizures
 * definition and how they are different from other seizures
 * atypical/typical

Drug Therapies and Experiments to Remedy Spike-and-Wave

 * (AEDs) antiepileptic drugs (Ferro article)
 * Experiments done on mice
 * Valproate and Ethosuximide for the treatment of childhood absence seizures (Beydoun article)