User:Ml17k/sandbox

outline questions:

1) summarizes your article and says why it is important that it be accurate and updated

My article talks about an essencial protein complex called Troponin Complex found in striated muscles. It is composed of three sub-units: Troponin T (tropomyosin binding sub-unit), Troponin C (calcium binding sub-unit), and Troponin I (inhibitory sub-unit). Due to the fact that mutations in any of those sub-units could lead to different cardiomyopathies, It is important to briefly list mutations and their respective cardiac phenotypes.

2) name specifically which parts, sections, or paragraphs assigned to you.

I am editing section 3 titled "Relation with contractile function and heart failure".

3) summarize your plan or suggestions for improvement (i.e. discuss what to improve, not yet making the specific edits - just your plan for the instructor to review and give feedback.

This session is really important but the given information is totally incomplete. There are so much that could be added like examples of mutations that could cause hypertrophy. I will also add information about different types of cardiomyopathies caused by mutations in different troponin sub-units.

4) Create a section in your Sandbox titled "Bibliography" and compile a list of relevant, reliable books, journal articles, or other sources that you will use to support your work. Post that bibliography to the talk page of the article you'll be working on, and in your sandbox. Make sure to check in on the Talk page to see if anyone has advice on your bibliography.

Mutations in the cardiac troponin subunits can result in cardiomyopathies, including hypertrophic (HCM), dilated (DCM) and restrictive (RCM) cardiomyopathies. Some amino acids are more likely to be substituted by others such as arginine that account for more than 60% of the mutations in troponin T sub-unit leading to dilated cardiomyopathy. The number of new troponin mutations has increased every year since their discovery in 1993. Examples of mutations in troponin complex sub-units:
 * HCM Mutations in troponin C: A8V, L29Q , A31S , C84Y , E134D.


 * DCM Mutations in Troponin C: Y5H, Q50R , E59D/D75Y , M103I , I148V , G159D.


 * HCM Mutations in troponin I: R21C, P82S, R141Q, A157V, R162P, R162W, G203S, and K206Q.


 * DCM Mutations in Troponin I: A2V.


 * RCM Mutations in Troponin I: L144Q, R145W, and R192H.


 * HCM Mutations in troponin T: I79N, R286H.


 * DCM Mutations in troponin T: R113W, R131G , D270N.


 * RCM Mutations in Troponin T: E136K.

Bibliography: