User:Mmahmed1/Gut microbiota/Parismm Peer Review

General info

 * Whose work are you reviewing?

(provide username)

Mmahmed1


 * Link to draft you're reviewing
 * User:Mmahmed1/Gut microbiota
 * Link to the current version of the article (if it exists)
 * Link to the current version of the article (if it exists)

Evaluate the drafted changes
(Compose a detailed peer review here, considering each of the key aspects listed above if it is relevant. Consider the guiding questions, and check out the examples of what feedback looks like.)


 * The statements in the article are lacking reference. Please cite them.
 * You need more than one reference for the final version of the article.
 * I think the focus of the article should be more on the chemical and ecological aspects of the gut microbiota. I do not see an association between the effects of gut microbiota on drugs and ecology. I would suggest to focus on which species and how (by the means of what chemicals) microbial communities are leaving these impacts on the drugs.
 * For each section, please elaborate more on the topic before providing the examples.

Second Peer Review
In general, a reasonable structure should be from broad to specific. In the following lines, I made some comments on the text starting from line two. Hope you find them helpful.

Line 2: "very long time ago when digoxin ", please specify when exactly

With new advancements in gene sequencing,

Drug absorption is the process of

", while the distribution of the drug is the transfer to the target site of action." this sentence is not grammatically correct.

"Gut microbiota also play roles in drug bioavailability and toxicity by activating, inactivating, and inducing toxicities" (I don't understand this phrase "inducing toxicities")

This community has huge biochemical capabilities o produce distinct secondary metabolites that are either produced from

In this sentence "Short Chain Fatty Acids (SCFAs) such as butyrate can support the innate immune system", the reader has no prior knowledge on how the Short Chain Fatty Acids (SCFAs) are associated with the roles of gut microbiota.

Indole-derived (no space)

Secondary metabolites produced by gut microbiota play crucial roles for the human host'''. For'''