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The nano-scaffold is a three-dimensional structure composed of polymer fibers very small that are scaled from a Nanometer (10-9 m) scale.

Electrospun nanofibers are prepared using microscopic tubes that range between 100 to 200 nanometers in diameter. These entangle with eachother in the form of a web as they're produced. Electrospinning allows the construction of these webs to be controlled in the sense of the tube's diameter, thickness, and the material being used.

Nanoscaffolding provides a large surface area for the material being produced, along with changeable chemical and physical properties. This allows them to be applicable in many different types of technological fields.