User:Mohammad.rahman744/sandbox

Glucokinase
Glucokinase (GK) is an enzyme that helps in the glycolytic pathway phosphorylating glucose into glucose-6-phosphate (G6P). It is an isozyme of hexokinase and is found mainly in pancreatic β cells liver, gut, and brain where glycolysis cause glucose-induced insulin secretion. Glucokinase activator lowers blood glucose concentrations by enhancing glucose uptake in the liver and increasing insulin production by the pancreatic β cells. Due to this, Glucokinase and glucokinase activators are the focus of treatment for those with type 2 diabetes mellitus. Glucokinase have a single allosteric site where the glucose-regulating protein (GKRP) binds in the nucleus of the cell in its inactive form, when there is low concentration of glucose present in the cell. However, when the glucose concentration of the cell increases the glucokinase-GKRP complex breaks apart and GK proceeds to the cytoplasm where it then phosphorylates glucose. Glucose when abundant in cells acts as an enzyme activator for glucokinase. Glucokinase activation in the β cells and liver cells results in the uptake of glucose and production of glycogen. This activation in the β cells leads to insulin secretion, promoting glucose uptake storing it as glycogen in the muscles.