User:Molonyc/Chromatolysis

Wikipedia Project Proposal: Chromatolysis
Aeri Alexander, Michele Kelley, Christian Molony, Robert Olp

General Definition
Chromatolysis is the disintegration of chromophil, a substance found in the body of a nerve cell, which can result from cell exhaustion or damage to peripheral processes. Axonal damage can lead to various physical or biochemical changes in the neuronal cell body. Cytoskeleton alterations are the main cellular reaction to chromatolysis. Based on their location within the brain, some neurons appear to be more susceptible to peripheral chromatolysis.

Types
1. Central Chromatolysis

2. Peripheral Chromatolysis

Causes

 * Axotomy (severe damage to axon)


 * Lithium Poisoning


 * Acrylamide Intoxication

Chemical Mechanisms

 * Nissl bodies


 * Chromophil

Diseases

 * Fetal Alcohol Syndrome


 * Alzheimer’s


 * ALS


 * Prick’s Disease


 * Corticobasal Degeneration