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Dr. Motibhai Desaibhai Patel was born on 3 March 1898 in Navli (District Kaira), in the Indian state of Gujarat. He was the first in the state to receive the professional qualification of Fellowship of the Royal College of Surgeons (FRCS) on 5 December 1930. FRCS is a fellowship bestowed to practice as a senior surgeon in Ireland or the United Kingdom. Soon after achieving highest surgical qualification, Dr. Patel returned from England to India and started consulting surgical practice in Bombay. He was persuaded by the late Sardar Vallabhbhai Patel to be a honorary superintendent of Sheth V.S. General Hospital in Ahmedabad in 1932.

During a span of about forty five years of active life, Dr. Patel has been a pioneering in the field of medicine.