User:Mozaffarafaque

       This Wiki is being used to track the progress of Term project on Interaction in           Protein - Protein Complex under the guidance of Abyayananda Maiti.

Problem statement : A protein complex (or multimeric protein) is a group of two or more proteins. Protein complexes are a form of quaternary structure. Proteins in a protein complex are linked by non-covalent protein-protein interactions, and different protein complexes have different degrees of stability over time. The task is to construct a bipartite network where one set of nodes is fixed as a set of proteins. Other set is the set of complexes and this set is assumed to be growing. We have to model Protein-Protein complex networks of a couple of organisms (i.e. human, yeast etc.). First job is to collect the data for different organism (However protein complex data for yeast is available in compact format in http://yeast-complexes.embl.de/complexview.pl?rm=home). Next we will analyze the networks with the help of existing bipartite network growth theory

Plan of Action: 1 Collect data 2 Literature Survey. 3 Build Bipartite Network. 4 Find The degree distribution of the bipartite network. 5 Analysis of the network using Growth model with one partition Fixed.

References : 1. Emergence of a non-scaling degree distribution in bipartite networks: A numerical and analytical study F. Peruani, M. Choudhury, A. Mukherjee and N. Ganguly 2. Modeling Discrete Combinatorial Systems as Alphabetic Bipartite Networks (α-BiNs): Theory and Applications 3. Growth Models of Bipartite Network with one Partition Fixed - A Maiti and N Ganguly.