User:Mr. Ibrahem/ACAM2000 smallpox vaccine

ACAM2000 is a smallpox vaccine to protect against smallpox and mpox (monkeypox). A single dose is generally only used in those at high risk of disease. It is given by pricking the skin of the upper arm several times with a 2-pronged needle which has been dipped in the vaccine. Similar vaccines have been used in all age groups. A booster dose may be given every three to ten years in those with continuing high risk.

Common side effects include reactions at the site it was given, swollen lymph nodes, fever, and tiredness. Other side effects may include myocarditis, pericarditis, encephalitis, and vaccinia. While use in pregnancy may harm the baby, such use may be warranted after exposure to smallpox. It contains live vaccinia virus which can spread to close contacts.

ACAM2000 was approved for medical use in the United States in 2007. By 2008, it replaced Dryvax, the prior vaccine of choice for preventing smallpox. It is manufactured by Emergent Product Development Gaithersburg and made in cell culture. In 2008 it costs governments about 5 USD per dose.