User:Mr. Ibrahem/Alosetron

Alosetron, sold under the brand name Lotronex among others, is a medication used for diarrhea-predominant irritable bowel syndrome (IBS) in women. It should only be used in those with severe disease who cannot be managed with other treatments. It is taken by mouth.

Common side effects include constipation, abdominal pain, and nausea. Other side effects may include bowel obstruction and ischemic colitis. Safety in pregnancy is unclear. It is a 5-HT3 receptor blocker.

Alosetron was patented in 1987 and came into medical use in the 1990s. It was temporarily withdrawn in 2000 due to isssues with constipation but was reintroduced in 2002. It is available as a generic medication. In the United States a month costs about 240 USD as of 2022.