User:Mr. Ibrahem/Amodiaquine/sulfadoxine/pyrimethamine

Amodiaquine/sulfadoxine/pyrimethamine are three medications sold together to prevent malaria. Specifically it is used to prevent falciparum malaria in children 3 months to 5 years old in sub-Saharan Africa. It is taken by mouth. It is given over three days once per month for up to 4 months.

Common side effects include vomiting, abdominal pain, diarrhea, headache, and allergic reactions. Liver problems and Steven–Johnson syndrome may occur. It should not be taken with sulfamethoxazole. Pyrimethamine/sulfadoxine use in early pregnancy may harm the baby; though maybe used in later pregnancy. It contains amodiaquine tablets, which blocks haem detoxification; and pyrimethamine/sulfadoxine tablets, which blocks dihydropteroate synthase and plasmodial dihydrofolate reductase.

The combination received World Health Organization prequalification in 2014. It is on the World Health Organization's List of Essential Medicines. Fifty courses of treatment costs about 16 USD as of 2023.