User:Mr. Ibrahem/Angiotensin II receptor blocker

Angiotensin II receptor blockers (ARBs), also known as angiotensin receptor blockers, are a class of medication primarily used to treat high blood pressure, heart failure, coronary heart disease, and kidney disease. They are taken by mouth. Their use with ACE inhibitors is not recommended.

Side effects can include low blood pressure, high potassium, and kidney problems. Kidney problems are more likely in those with renal artery stenosis. Compared to ACE inhibitors they are less likely to cause cough or angioedema. Use during pregnancy can harm the baby. They work by blocking the angiotensin II receptor type 1 (AT1) thereby preventing the effects of angiotensin II. This results in dilation of blood vessels and increased release of water and sodium by the kidneys.

ARBs, specifically losartan, came into medical use in 1995. Some are available as generic medication and are not very expensive. In the United States losartan and irbesartan were the least expensive at about US$90 per month in 2016. In the United States they are a first line treatment for high blood pressure, along with calcium channel blockers, thiazide diuretics, and ACE inhibitors.